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Sex Differences in ACTH Pulsatility following Metyrapone Blockade in Patients with Major Depression

dc.contributor.authorYoung, Elizabeth A.en_US
dc.contributor.authorRibeiro, Saulo C. M.en_US
dc.contributor.authorYe, Wenen_US
dc.date.accessioned2007-03-16T18:28:45Z
dc.date.available2007-03-16T18:28:45Z
dc.date.issued2006-03-13en_US
dc.identifier.citationPsychoneuroendocrinology, in press <http://hdl.handle.net/2027.42/49490>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49490
dc.descriptionpre-printen_US
dc.description.abstractNumerous studies suggest that increased central drive to the hypothalamic-pituitary adrenal axis occurs in patients with major depression. To determine if increased central drive occurs throughout the 24H, we evaluated ACTH secretion under metyrapone blockade of cortisol production. We collected blood every 10 minutes for measurement of ACTH and data were analyzed for ACTH pulsatility using the pulse detection algorithm deconvolution. We studied 28 patients with major depression and 28 age and sex matched control subjects, of which 9 pairs were men and 19 pairs were women. We found a significant group by sex interaction with number of ACTH pulses (p=.04); depressed men showed more ACTH pulses over 24H than matched control men (p=0.02). There was also a significant sex difference in AUC pulses with men showing a smaller AUC ACTH than women. Previous analyses of these data with RM-ANOVA showed a smaller ACTH response in depressed men compared to control men. These data suggest that pulsatility and mean ACTH levels are examining different aspects of HPA axis function, and that the types of HPA axis dysregulation in depression may differ between men and women.en_US
dc.description.sponsorshipNIMH MH50030en_US
dc.format.extent1347 bytes
dc.format.extent64512 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/msword
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectDepressionen_US
dc.subjectHormone Pulsatilityen_US
dc.titleSex Differences in ACTH Pulsatility following Metyrapone Blockade in Patients with Major Depressionen_US
dc.title.alternativeSex differences in ACTH pulsatilityen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPsychiatryen_US
dc.contributor.affiliationumMolecular and Behavioral Neurosciences Instituteen_US
dc.contributor.affiliationotherPsychiatryen_US
dc.contributor.affiliationotherBiostatisticsen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49490/2/PulseMetrev3-2007.docen_US
dc.identifier.sourcePsychoneuroendocrinologyen_US
dc.owningcollnameMolecular and Behavioral Neurosciences Institute


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