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Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood

dc.contributor.authorGurney, James G.en_US
dc.contributor.authorNess, Kirsten K.en_US
dc.contributor.authorRosenthal, Josephen_US
dc.contributor.authorForman, Stephen J.en_US
dc.contributor.authorBhatia, Smitaen_US
dc.contributor.authorBaker, K. Scotten_US
dc.date.accessioned2007-03-19T17:25:37Z
dc.date.available2007-03-19T17:25:37Z
dc.date.issued2006-03-15en_US
dc.identifier.citationGurney, James G.; Ness, Kirsten K.; Rosenthal, Joseph; Forman, Stephen J.; Bhatia, Smita; Baker, K. Scott (2006)."Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood." Cancer 106(6): 1402-1408. <http://hdl.handle.net/2027.42/49517>en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.issn1097-0142en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49517
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16453335&dopt=citationen_US
dc.description.abstractBACKGROUND Because of treatment-related toxicity, research is increasingly being focused on long-term sequelae secondary to hematopoietic stem cell transplantation (HSCT) in survivor populations. METHODS This study describes the incidence of auditory, sensory, motor, and visual impairments, including cataracts, among 235 individuals who were treated with HSCT during childhood or adolescence. Outcomes were compared with 705 siblings of childhood cancer survivors. Participants completed a survey with questions on posttransplant organ system impairments. Approximately half of survivors were transplanted when younger than 10 years of age. The median length of followup was 11 years. RESULTS The cumulative incidence of cataracts was 36% at 15 years post-HSCT, although cataracts occurred only in those who received total body irradiation as an HSCT conditioning agent or head irradiation before transplant. Persistent pain was reported by 21% of survivors. Loss of hearing in one or both ears, and legal blindness in one or both eyes, each occurred after transplant in 2% of survivors. Occurrences were uncommon, but survivors were 4.3 times (95% confidence interval [CI]: 2.0–9.4) more likely to report coordination problems, 7.7 times (95% CI: 3.2–18.5) more likely to report chewing or swallowing problems, and 3.5 times (3.5; 95% CI: 1.6–7.9) more likely to report muscle weakness than those in the comparison group. Muscle weakness was strongly associated with positive history of chronic graft-versus-host disease. CONCLUSIONS Increased risks were found for motor impairments, hearing loss, vision loss, and persistent pain among study participants. Cataracts were a frequent adverse effect, suggesting that close monitoring with appropriate intervention for preservation of vision, particularly among those who received total body irradiation, should be a primary goal in survivors of HSCT performed in childhood. Cancer 2006. © 2006 American Cancer Society.en_US
dc.format.extent103211 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleVisual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhooden_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 764-2599 ; University of Michigan, Division of General Pediatrics, 300 NIB 6E02 Box 0456, 300 N. Ingalls St., Ann Arbor, MI 48109-0456en_US
dc.contributor.affiliationotherDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesotaen_US
dc.contributor.affiliationotherDepartment of Pediatrics, City of Hope Cancer Center, Duarte, Californiaen_US
dc.contributor.affiliationotherDepartment of Pediatrics, City of Hope Cancer Center, Duarte, Californiaen_US
dc.contributor.affiliationotherDepartment of Pediatrics, City of Hope Cancer Center, Duarte, Californiaen_US
dc.contributor.affiliationotherDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesotaen_US
dc.identifier.pmid16453335en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49517/1/21752_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cncr.21752en_US
dc.identifier.sourceCanceren_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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