Attenuation of half sulfur mustard gas-induced acute lung injury in rats
dc.contributor.author | McClintock, Shannon D. | en_US |
dc.contributor.author | Hoesel, Laszlo M. | en_US |
dc.contributor.author | Das, Salil K. | en_US |
dc.contributor.author | Till, Gerd O. | en_US |
dc.contributor.author | Neff, Thomas | en_US |
dc.contributor.author | Kunkel, Robin G. | en_US |
dc.contributor.author | Smith, Milton G. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.date.accessioned | 2007-03-19T17:26:07Z | |
dc.date.available | 2007-03-19T17:26:07Z | |
dc.date.issued | 2006-03 | en_US |
dc.identifier.citation | McClintock, Shannon D.; Hoesel, Laszlo M.; Das, Salil K.; Till, Gerd O.; Neff, Thomas; Kunkel, Robin G.; Smith, Milton G.; Ward, Peter A. (2006)."Attenuation of half sulfur mustard gas-induced acute lung injury in rats." Journal of Applied Toxicology 26(2): 126-131. <http://hdl.handle.net/2027.42/49522> | en_US |
dc.identifier.issn | 0260-437X | en_US |
dc.identifier.issn | 1099-1263 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49522 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16252256&dopt=citation | en_US |
dc.description.abstract | Airway instillation into rats of 2-chloroethyl ethyl sulfide (CEES), the half molecule of sulfur mustard compound, results in acute lung injury, as measured by the leak of plasma albumin into the lung. Morphologically, early changes in the lung include alveolar hemorrhage and fibrin deposition and the influx of neutrophils. Following lung contact with CEES, progressive accumulation of collagen occurred in the lung, followed by parenchymal collapse. The co-instillation with CEES of liposomes containing pegylated (PEG)-catalase (CAT), PEG-superoxide dismutase (SOD), or the combination, greatly attenuated the development of lung injury. Likewise, the co-instillation of liposomes containing the reducing agents, N-acetylcysteine (NAC), glutathione (GSH), or resveratrol (RES), significantly reduced acute lung injury. The combination of complement depletion and airway instillation of liposomes containing anti-oxidant compounds maximally attenuated CEES-induced lung injury by nearly 80%. Delayed airway instillation of anti-oxidant-containing liposomes (containing NAC or GSH, or the combination) significantly diminished lung injury even when instillation was delayed as long as 1 h after lung exposure to CEES. These data indicate that CEES-induced injury of rat lungs can be substantially diminished by the presence of reducing agents or anti-oxidant enzymes delivered via liposomes. Copyright © 2005 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 308661 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Occupational Health and Environmental Toxicology | en_US |
dc.title | Attenuation of half sulfur mustard gas-induced acute lung injury in rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA ; Amaox, Ltd, Paw Paw, MI 49079, USA ; The University of Michigan Medical School, Department of Pathology, 1301 Catherine Rd, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationother | Meharry Medical School, Department of Biochemistry, Nashville, TN, USA | en_US |
dc.identifier.pmid | 16252256 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49522/1/1115_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jat.1115 | en_US |
dc.identifier.source | Journal of Applied Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.