Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation
dc.contributor.author | Booth, Victoria | en_US |
dc.contributor.author | Poe, Gina R. | en_US |
dc.date.accessioned | 2007-03-19T17:27:09Z | |
dc.date.available | 2007-03-19T17:27:09Z | |
dc.date.issued | 2006-02 | en_US |
dc.identifier.citation | Booth, Victoria; Poe, Gina R. (2006)."Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation." Hippocampus 16(2): 161-173. <http://hdl.handle.net/2027.42/49532> | en_US |
dc.identifier.issn | 1050-9631 | en_US |
dc.identifier.issn | 1098-1063 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49532 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16411243&dopt=citation | en_US |
dc.description.abstract | In simulation studies using a realistic model CA1 pyramidal cell, we accounted for the shift in mean firing phase from theta cycle peaks to theta cycle troughs during rapid-eye movement (REM) sleep reactivation of hippocampal CA1 place cells over several days of growing familiarization with an environment (Brain Res 855:176–180). Changes in the theta drive phase and amplitude between proximal and distal dendritic regions of the cell modulated the theta phase of firing when stimuli were presented at proximal and distal dendritic locations. Stimuli at proximal dendritic sites (proximal to 100 Μm from the soma) invoked firing with a significant phase preference at the depolarizing theta peaks, while distal stimuli (>290 Μm from the soma) invoked firing at hyperpolarizing theta troughs. The input location-related phase preference depended on active dendritic conductances, a sufficient electrotonic separation between input sites and theta-induced subthreshold membrane potential oscillations in the cell. The simulation results predict that the shift in mean theta phase during REM sleep cellular reactivation could occur through potentiation of distal dendritic (temporo-ammonic) synapses and depotentiation of proximal dendritic (Schaffer collateral) synapses over the course of familiarization. © 2006 Wiley-Liss, Inc. | en_US |
dc.format.extent | 629890 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Anesthesiology, 7433 Medical Science Building I, 1150 West Medical Center Drive, Ann Arbor, MI 48109-9332 | en_US |
dc.contributor.affiliationum | Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 16411243 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49532/1/20143_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hipo.20143 | en_US |
dc.identifier.source | Hippocampus | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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