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Local action of intrahypophyseal implants of estrogen as revealed by staining with peroxidase-labeled antibody Supported in part by research grants from the USPHS (HD 03159-02) and from the University of Michigan Horace H. Rackham School of Graduate Studies.

dc.contributor.authorGersten, Brian E.en_US
dc.contributor.authorBaker, Burton L.en_US
dc.date.accessioned2007-04-06T17:41:11Z
dc.date.available2007-04-06T17:41:11Z
dc.date.issued1970-05en_US
dc.identifier.citationGersten, Brian E.; Baker, Burton L. (1970)."Local action of intrahypophyseal implants of estrogen as revealed by staining with peroxidase-labeled antibody Supported in part by research grants from the USPHS (HD 03159-02) and from the University of Michigan Horace H. Rackham School of Graduate Studies. ." American Journal of Anatomy 128(1): 1-19. <http://hdl.handle.net/2027.42/49649>en_US
dc.identifier.issn0002-9106en_US
dc.identifier.issn1553-0795en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49649
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4193920&dopt=citationen_US
dc.description.abstractThe direct action of 17 Β-estradiol and cholesterol on cells of the pituitary pars distalis, as revealed by staining with peroxidase-labeled antibody, was studied in female rats. Pellets of pure cholesterol and of estradiol mixed with cholesterol were implanted into the left lobe of the pars distalis 14–32 days after ovariectomy and left in place for 7–16 days. Rabbit antisera to rat prolactin, human growth hormone, human chorionic gonadotropin (for gonadotropes — presumably luteinizing hormone cells), and porcine corticotropin were used. In no case were cells altered in the contralateral lobe of the pars distalis; cholesterol likewise had no significant effect on the ipsilateral lobe. However, in the ipsilateral lobe containing an estrogen pellet, prolactin cells were hypertrophied and hyperplastic; cells assumed to be responsible for luteinizing hormone secretion were reduced in size and stained more intensely; and growth hormone cells were reduced in size. Corticotropin cells remained unaffected. For the most part estrogenic effects were distributed ventrally, caudally and laterally from the pellet and not far medially, never reaching the midline. It was concluded that estrogen acts directly on the hypophysis, the spread of the effects reflecting the direction of blood flow within the gland. These observations support the hypothesis that the pituitary gland serves as a site for feedback action by estrogen.en_US
dc.format.extent1816649 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleLocal action of intrahypophyseal implants of estrogen as revealed by staining with peroxidase-labeled antibody Supported in part by research grants from the USPHS (HD 03159-02) and from the University of Michigan Horace H. Rackham School of Graduate Studies.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy, The University of Michigan Medical School, Ann Arbor, Michigan 48104en_US
dc.contributor.affiliationumDepartment of Anatomy, The University of Michigan Medical School, Ann Arbor, Michigan 48104en_US
dc.identifier.pmid4193920en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49649/1/1001280102_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/aja.1001280102en_US
dc.identifier.sourceAmerican Journal of Anatomyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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