A fine structural study of divalent cation-mediated epithelial union with connective tissue in human oral mucosa
dc.contributor.author | Scaletta, Lawrence J. | en_US |
dc.contributor.author | MacCallum, Donald K. | en_US |
dc.date.accessioned | 2007-04-06T17:42:11Z | |
dc.date.available | 2007-04-06T17:42:11Z | |
dc.date.issued | 1972-04 | en_US |
dc.identifier.citation | Scaletta, Lawrence J.; MacCallum, Donald K. (1972)."A fine structural study of divalent cation-mediated epithelial union with connective tissue in human oral mucosa." American Journal of Anatomy 133(4): 431-453. <http://hdl.handle.net/2027.42/49659> | en_US |
dc.identifier.issn | 0002-9106 | en_US |
dc.identifier.issn | 1553-0795 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49659 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4622729&dopt=citation | en_US |
dc.description.abstract | Following incubation in an isotonic saline solution containing 20 mM EDTA, human oral mucosa may be separated into its epithelial and connective tissue components. Ultrastructural study of the separated tissues reveals that the plane of separation is through the lamina lucida. Hemidesmosomal structure is altered by the separation process: the peripheral density is absent but a fine, generally filamentous material remains associated with the outer membrane leaflet of the hemidesmosome. Desmosome structure is not altered. An intact lamina densa remains attached to the connective tissue fragment. Oral mucosa incubated in EDTA-saline containing calcium, or its return to a divalent cation-supplemented medium after treatment with EDTA, prevents separation. By maintaining the structural integrity of the hemidesmosome, divalent cations appear to play a principal role in uniting oral mucosal epithelium to the lamina propria. | en_US |
dc.format.extent | 2105870 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | A fine structural study of divalent cation-mediated epithelial union with connective tissue in human oral mucosa | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | School of Dentistry, Case Western Reserve University, Cleveland, Ohio 44106 and Departments of Oral Biology and Anatomy, University of Michigan, Ann Arbor, Michigan 48104 | en_US |
dc.contributor.affiliationum | School of Dentistry, Case Western Reserve University, Cleveland, Ohio 44106 and Departments of Oral Biology and Anatomy, University of Michigan, Ann Arbor, Michigan 48104 | en_US |
dc.identifier.pmid | 4622729 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49659/1/1001330406_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/aja.1001330406 | en_US |
dc.identifier.source | American Journal of Anatomy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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