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dc.contributor.authorBaker, Burton L.en_US
dc.contributor.authorJaffe, Robert B.en_US
dc.date.accessioned2007-04-06T17:43:41Z
dc.date.available2007-04-06T17:43:41Z
dc.date.issued1975-06en_US
dc.identifier.citationBaker, Burton L.; Jaffe, Robert B. (1975)."The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry Supported in part by research grants from the National Institutes of Health, HD-03159-06 to Dr. B. L. Baker and HD-08478 to Dr. R. B. Jaffe. ." American Journal of Anatomy 143(2): 137-161. <http://hdl.handle.net/2027.42/49674>en_US
dc.identifier.issn0002-9106en_US
dc.identifier.issn1553-0795en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49674
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=167574&dopt=citationen_US
dc.description.abstractHypophyses of 21 human fetuses, ranging in gestational age from 6 to 23 weeks, were studied by immunocytochemical and histological staining to ascertain (1) the time of origin of specific cell types and (2) the development of parenchymal cell zonation in the pars distalis. No hormones were identified at six weeks. Probable corticotrophin-containing cells appeared at seven weeks. Somatotrophs were observed first at 10.5 weeks; correlation with other reports indicates that they appear at eight to nine weeks. Melanotrophs were detected at 14 weeks; the cells containing melanotrophin were far fewer than corticotrophs. The youngest fetus to possess gonadotrophs was 10.5 weeks old. In all specimens gonadotrophs (LH-cells) stained well with immunocytochemical procedures but poorly with histological methods. Thyrotrophs first occurred at 13 weeks. Zonal distribution of cell types in the pars distalis was evident almost from the time of their appearance. Somatotrophs were most numerous laterally and immediately anterior to the residual cleft. At 10.5 weeks corticotrophs were confined chiefly to the borders of vascularized connective tissue (trabeculae) and to the lateral peripheral region of the pars distalis. Thyrotrophs appeared chiefly in the anteromedian zone, particularly in its superior portion, but were found laterally also. In the older specimens, gonadotrophs generally occurred throughout the pars distalis but were less numerous near the trabeculae and in the anterolateral region. There was good correlation between the time of appearance of various cell types and published data on secretory capacity of the gland.en_US
dc.format.extent2328325 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleThe genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry Supported in part by research grants from the National Institutes of Health, HD-03159-06 to Dr. B. L. Baker and HD-08478 to Dr. R. B. Jaffe.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy and Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48104en_US
dc.contributor.affiliationumDepartment of Anatomy and Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 ; We express our appreciation to Mrs. Ya-Yen Yu and Mrs. Frances Wicks for their expert technical assistance.en_US
dc.identifier.pmid167574en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49674/1/1001430202_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/aja.1001430202en_US
dc.identifier.sourceAmerican Journal of Anatomyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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