The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry Supported in part by research grants from the National Institutes of Health, HD-03159-06 to Dr. B. L. Baker and HD-08478 to Dr. R. B. Jaffe.

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dc.contributor.author Baker, Burton L. en_US
dc.contributor.author Jaffe, Robert B. en_US
dc.date.accessioned 2007-04-06T17:43:41Z
dc.date.available 2007-04-06T17:43:41Z
dc.date.issued 1975-06 en_US
dc.identifier.citation Baker, Burton L.; Jaffe, Robert B. (1975)."The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry Supported in part by research grants from the National Institutes of Health, HD-03159-06 to Dr. B. L. Baker and HD-08478 to Dr. R. B. Jaffe. ." American Journal of Anatomy 143(2): 137-161. <http://hdl.handle.net/2027.42/49674> en_US
dc.identifier.issn 0002-9106 en_US
dc.identifier.issn 1553-0795 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/49674
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=167574&dopt=citation en_US
dc.description.abstract Hypophyses of 21 human fetuses, ranging in gestational age from 6 to 23 weeks, were studied by immunocytochemical and histological staining to ascertain (1) the time of origin of specific cell types and (2) the development of parenchymal cell zonation in the pars distalis. No hormones were identified at six weeks. Probable corticotrophin-containing cells appeared at seven weeks. Somatotrophs were observed first at 10.5 weeks; correlation with other reports indicates that they appear at eight to nine weeks. Melanotrophs were detected at 14 weeks; the cells containing melanotrophin were far fewer than corticotrophs. The youngest fetus to possess gonadotrophs was 10.5 weeks old. In all specimens gonadotrophs (LH-cells) stained well with immunocytochemical procedures but poorly with histological methods. Thyrotrophs first occurred at 13 weeks. Zonal distribution of cell types in the pars distalis was evident almost from the time of their appearance. Somatotrophs were most numerous laterally and immediately anterior to the residual cleft. At 10.5 weeks corticotrophs were confined chiefly to the borders of vascularized connective tissue (trabeculae) and to the lateral peripheral region of the pars distalis. Thyrotrophs appeared chiefly in the anteromedian zone, particularly in its superior portion, but were found laterally also. In the older specimens, gonadotrophs generally occurred throughout the pars distalis but were less numerous near the trabeculae and in the anterolateral region. There was good correlation between the time of appearance of various cell types and published data on secretory capacity of the gland. en_US
dc.format.extent 2328325 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cell & Developmental Biology en_US
dc.title The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry Supported in part by research grants from the National Institutes of Health, HD-03159-06 to Dr. B. L. Baker and HD-08478 to Dr. R. B. Jaffe. en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Medicine (General) en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Anatomy and Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 en_US
dc.contributor.affiliationum Department of Anatomy and Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 ; We express our appreciation to Mrs. Ya-Yen Yu and Mrs. Frances Wicks for their expert technical assistance. en_US
dc.identifier.pmid 167574 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/49674/1/1001430202_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/aja.1001430202 en_US
dc.identifier.source American Journal of Anatomy en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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