Immunohistochemical localization of gonadotropin-releasing hormone (GnRH) in the fetal and early postnatal mouse brain Supported in part by a Program Project Grant (HD-08333) directed by Dr. A. R. Midgley, Jr., from the National Institute for Child Health and Human Development.
dc.contributor.author | Gross, Douglas S. | en_US |
dc.contributor.author | Baker, Burton L. | en_US |
dc.date.accessioned | 2007-04-06T17:43:53Z | |
dc.date.available | 2007-04-06T17:43:53Z | |
dc.date.issued | 1977-02 | en_US |
dc.identifier.citation | Gross, Douglas S.; Baker, Burton L. (1977)."Immunohistochemical localization of gonadotropin-releasing hormone (GnRH) in the fetal and early postnatal mouse brain Supported in part by a Program Project Grant (HD-08333) directed by Dr. A. R. Midgley, Jr., from the National Institute for Child Health and Human Development. ." American Journal of Anatomy 148(2): 195-215. <http://hdl.handle.net/2027.42/49676> | en_US |
dc.identifier.issn | 0002-9106 | en_US |
dc.identifier.issn | 1553-0795 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49676 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=322467&dopt=citation | en_US |
dc.description.abstract | The objectives were to (a) determine the age in development when GnRH is first detectable in the brain and (b) observe the distribution of GnRH throughout the fetal and early postnatal period. GnRH was localized immunohistochemically in fetal (15, 16, 17 and 19 days of gestation) and early postnatal (1- and 7-day-old) mice with the peroxidase-antiperoxidase (PAP) method of Sternberger. In the organum vasculosum of the lamina terminalis (OVLT) and in the median eminence of the fetus, GnRH was first detected at 17 days of gestation. In the OVLT, GnRH was found ventral to the preoptic recess of the third ventricle near the ventral surface of the brain. In addition, GnRH was located adjacent to the superficial portal capillaries near the surface of the median eminence. At 19 days of gestation, the distribution of GnRH was similar to that observed at 17 days and there was a marked increase in amount. In the newborn mouse, GnRH was undetectable in the OVLT and its content in the median eminence was decreased as compared to that observed in the fetus. By the seventh postnatal day, a considerable accumulation of GnRH had occurred in the OVLT and median eminence. In the OVLT, it was associated with capillaries ventral to the preoptic recess, and its distribution in the median eminence was similar to that in the adult mouse. In both the OVLT and median eminence of the fetal and early postnatal mouse GnRH appeared to be stored in axons and axon endings, but was not detectable in nerve cell bodies or ependymal cells. These observations suggest that the potential for neuroendocrine control of gonadotropin secretion exists in the fetal mouse as early as 17 days of gestation. | en_US |
dc.format.extent | 1865055 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Immunohistochemical localization of gonadotropin-releasing hormone (GnRH) in the fetal and early postnatal mouse brain Supported in part by a Program Project Grant (HD-08333) directed by Dr. A. R. Midgley, Jr., from the National Institute for Child Health and Human Development. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy and Reproductive Endocrinology Program, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Anatomy and Reproductive Endocrinology Program, The University of Michigan Medical School, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 322467 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49676/1/1001480203_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/aja.1001480203 | en_US |
dc.identifier.source | American Journal of Anatomy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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