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Survival of myogenic cells in freely grafted rat rectus femoris and extensor digitorum longus muscles

dc.contributor.authorPhillips, Gregg D.en_US
dc.contributor.authorLu, Danyunen_US
dc.contributor.authorMitashov, Victor I.en_US
dc.contributor.authorCarlson, Bruce M.en_US
dc.date.accessioned2007-04-06T17:45:35Z
dc.date.available2007-04-06T17:45:35Z
dc.date.issued1987-12en_US
dc.identifier.citationPhillips, Gregg D.; Lu, Danyun; Mitashov, Victor I.; Carlson, Bruce M. (1987)."Survival of myogenic cells in freely grafted rat rectus femoris and extensor digitorum longus muscles." American Journal of Anatomy 180(4): 365-372. <http://hdl.handle.net/2027.42/49693>en_US
dc.identifier.issn0002-9106en_US
dc.identifier.issn1553-0795en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49693
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3425564&dopt=citationen_US
dc.description.abstractThe objective of this study was to determine how long myogenic cells can survive in the central ischemic zone of early free muscle grafts in the rat. The study was conducted on free grafts of a large (rectus femoris) and a small (extensor digitorum lon-gus) muscle. At times ranging from zero hr to five days post-grafting, the central zones were isolated, minced, and implanted under the back skin of mice. After five days the minces were removed and examined histologically for the presence of rat myotubes, which should form only in minces that contain viable myogenic cells. The results show that myogenic cells survive two to four hr in the ischemic centers of the large rectus femoris grafts; after longer post-grafting intervals, rat myotubes did not arise in central zone minces. In grafts of small muscles, myotubes consistently appeared in central zone minces. Since the formerly ischemic central areas of rectus muscle grafts are ultimately replaced by regenerating muscle fibers, we conclude that these regenerating muscle fibers are derived from precursor cells located outside of the ischemic zone.en_US
dc.format.extent1370340 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleSurvival of myogenic cells in freely grafted rat rectus femoris and extensor digitorum longus musclesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109 ; University of Michigan, Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid3425564en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49693/1/1001800407_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/aja.1001800407en_US
dc.identifier.sourceAmerican Journal of Anatomyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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