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Studies on hypoxia V. Effects of anoxia on developing connective tissue cells in rats Supported in part by Grants HD-03147, DE-02311 and DE-02731 from the National Institutes of Health, U.S. Public Health Service.

dc.contributor.authorKim, Joon H.en_US
dc.contributor.authorHan, Seong Sooen_US
dc.date.accessioned2007-04-06T17:57:51Z
dc.date.available2007-04-06T17:57:51Z
dc.date.issued1969-12en_US
dc.identifier.citationKim, Joon H.; Han, Seong S. (1969)."Studies on hypoxia V. Effects of anoxia on developing connective tissue cells in rats Supported in part by Grants HD-03147, DE-02311 and DE-02731 from the National Institutes of Health, U.S. Public Health Service. ." The Anatomical Record 165(4): 531-541. <http://hdl.handle.net/2027.42/49816>en_US
dc.identifier.issn0003-276Xen_US
dc.identifier.issn1097-0185en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49816
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5356956&dopt=citationen_US
dc.description.abstractThe effect of anoxia on protein synthesis of developing connective tissue cells was studied by radioautography. Neonatal rats were subjected to anoxia for 20 minutes and were immediately injected with 3 Μc/gm body weight of leucine-H 3 intraperitoneally. They were sacrificed at different intervals after injection. Control animals were handled identically, except that atmospheric air was made available. The heads of the animals were prepared for radioautography in the standard manner. The number of grains was counted over individual fibrobalsts, osteoblasts and chondrocytes of histologically comparable regions, and the data were statistically evaluated. The number of grains per cell was significantly lower in experimental animals sacrificed at one hour after the anoxic treatment and leucine-H 3 administration. At this time, the average grain number per cell in the experimental animal was less than 50% of the control. The difference was about 20% by four hours and was negligible after 24 hours. The result is interpreted to indicate that the overall protein synthesis in connective tissues is immediately but temporarily suppressed by anoxia and that such suppression might lead to a later functional disturbance among these cells.en_US
dc.format.extent984810 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleStudies on hypoxia V. Effects of anoxia on developing connective tissue cells in rats Supported in part by Grants HD-03147, DE-02311 and DE-02731 from the National Institutes of Health, U.S. Public Health Service.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Cell Biology, Dental Research Institute and Department of Anatomy, University of Michiganen_US
dc.contributor.affiliationumLaboratory of Cell Biology, Dental Research Institute and Department of Anatomy, University of Michiganen_US
dc.identifier.pmid5356956en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49816/1/1091650408_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ar.1091650408en_US
dc.identifier.sourceThe Anatomical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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