Identification of the corticotropin cell in rat hypophyses with peroxidase-labeled antibody Supported in part by USPHS research grants HD 03159-01Al and HD 02193, and a grant from the University of Michigan Horace H. Rackham School of Graduate Studies.

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dc.contributor.author Baker, Burton L. en_US
dc.contributor.author Pek, Sumer Belbez en_US
dc.contributor.author Midgley, A. Rees en_US
dc.contributor.author Gersten, Brian E. en_US
dc.date.accessioned 2007-04-06T17:58:02Z
dc.date.available 2007-04-06T17:58:02Z
dc.date.issued 1970-04 en_US
dc.identifier.citation Baker, Burton L.; Pek, Sumer; Midgley, A. Rees; Gersten, Brian E. (1970)."Identification of the corticotropin cell in rat hypophyses with peroxidase-labeled antibody Supported in part by USPHS research grants HD 03159-01Al and HD 02193, and a grant from the University of Michigan Horace H. Rackham School of Graduate Studies. ." The Anatomical Record 166(4): 557-567. <http://hdl.handle.net/2027.42/49818> en_US
dc.identifier.issn 0003-276X en_US
dc.identifier.issn 1097-0185 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/49818
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4191040&dopt=citation en_US
dc.description.abstract Utilization of peroxidase-labeled antibody to porcine corticotropin permitted the delineation of a distinctive cell in the hypophyseal pars distalis of the rat that appears to be the source of corticotropin. Corticotropin cells were stellate and possessed processes that ended on the walls of sinusoids. Corticotropin cells composed a small percentage of the total cell population, and were distributed throughout the gland except that they were less common posteriorly, superiorly, and immediately alongside the pars intermedia. Alteration in size of corticotropin cells was related directly to change in corticotropin content of the gland as effected by differing physiological conditions. Thus, they were larger in the female than in the male and were enlarged after adrenalectomy of the male; they became much smaller following treatment of the female with cortisol. Some corticotropin cells stained with aldehyde fuchsin and the periodic acid-Schiff (PAS) reaction. These reactions were more intense if hormone antibody and the gamma-globulin conjugate had been applied previously. However, the capacity of some corticotropin cells to stain weakly with PAS without prior application of antibody suggests that they may contain mucoprotein. en_US
dc.format.extent 1023663 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cell & Developmental Biology en_US
dc.title Identification of the corticotropin cell in rat hypophyses with peroxidase-labeled antibody Supported in part by USPHS research grants HD 03159-01Al and HD 02193, and a grant from the University of Michigan Horace H. Rackham School of Graduate Studies. en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Departments of Anatomy, Internal Medicine and Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 en_US
dc.contributor.affiliationum Departments of Anatomy, Internal Medicine and Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 en_US
dc.contributor.affiliationum Departments of Anatomy, Internal Medicine and Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 en_US
dc.contributor.affiliationum Departments of Anatomy, Internal Medicine and Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 en_US
dc.identifier.pmid 4191040 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/49818/1/1091660402_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/ar.1091660402 en_US
dc.identifier.source The Anatomical Record en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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