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Presence and location of adrenergic nerve endings in the dental pulps of mouse molars

dc.contributor.authorAvery, James K.en_US
dc.contributor.authorCox, Charles F.en_US
dc.contributor.authorChiego, Daniel J. Jr.en_US
dc.date.accessioned2007-04-06T18:00:03Z
dc.date.available2007-04-06T18:00:03Z
dc.date.issued1980-09en_US
dc.identifier.citationAvery, James K.; Cox, Charles F.; Jr., Daniel J. (1980)."Presence and location of adrenergic nerve endings in the dental pulps of mouse molars." The Anatomical Record 198(1): 59-71. <http://hdl.handle.net/2027.42/49838>en_US
dc.identifier.issn0003-276Xen_US
dc.identifier.issn1097-0185en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49838
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7457931&dopt=citationen_US
dc.description.abstractIn all, 30 adult (45-day-old) Swiss Webster mice were used for light and electron microscopic examination of the presence, number, and location of adrenergic endings in the first molar teeth. Prior to sacrifice, 10 animals received i.p. injections at 8, 6, 4, and 2 hours of 0.5 cc of 20 mg/kg solution of 5-hydroxydopamine (5-OH-DA) as a label for adrenergic endings. The animals were then anesthetized, perfused with Karnovsky's fixative, and the teeth were postfixed in Osmic acid, decalcified, embedded in methacrylate, and serial-sectioned. The sections were surveyed by light microscopy, and the number and location of nerve endings containing the reduced 5-OH-DA were recorded. Ten control mice were injected with the vehicle solution and prepared in the same manner. A third series of mice were given a single injection of 5-OH-DA, sacrificed, and prepared for ultrastructural study. The molar pulps were divided into four areas to facilitate examination: pulp horns, coronal pulp, bifurcation area, and root pulp. These four areas were further divided into three zones: odontogenic, vascular-related, and nonvascular-associated. The location and number of endings were evaluated, and an average of approximately 70 endings containing the 5-OH-DA were found in each tooth using light microscopy. These represented 35.5 ± 5.2 in the pulp horns; 26.1 ± 2.4 in the central coronal; 5.4 ± 0.7 in the bifurcation, and 5.6 ± 0.9 in the root pulp per tooth. Vascular related endings were found in greatest number, the odontogenic zone next, and free endings least. Verification of location of 5-OH-DA by ultrastructural analysis revealed the false transmitter in vesiculated endings in the four areas and zones of the pulp.en_US
dc.format.extent1275369 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titlePresence and location of adrenergic nerve endings in the dental pulps of mouse molarsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Oral Histology, Dental Research Institute, The University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumLaboratory of Oral Histology, Dental Research Institute, The University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumLaboratory of Oral Histology, Dental Research Institute, The University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid7457931en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49838/1/1091980105_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ar.1091980105en_US
dc.identifier.sourceThe Anatomical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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