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dc.contributor.authorHansen-Smith, Fay M.en_US
dc.date.accessioned2007-04-06T18:00:38Z
dc.date.available2007-04-06T18:00:38Z
dc.date.issued1983-09en_US
dc.identifier.citationHansen-Smith, Fay M. (1983)."Development and innervation of soleplates in the freely grafted extensor digitorum longus (EDL) muscle in the rat." The Anatomical Record 207(1): 55-67. <http://hdl.handle.net/2027.42/49844>en_US
dc.identifier.issn0003-276Xen_US
dc.identifier.issn1097-0185en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49844
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6638533&dopt=citationen_US
dc.description.abstractThe ultrastructural events in the establishment of the neuromuscular junction of the freely grafted extensor digitorum longus (EDL) muscle of the rat were studied 1–120 days after grafting. The original axons and muscle fibers, including soleplates, degenerated during the first few days, but Schwann cells and basal laminae persisted. Myofibers regenerated within the original basal laminae. Indentations of the sarcolemma, termed “presumptive synaptic clefts” (PSC), wer found on myotubes from 7-day grafts. Schwann cells and residual acetylcholinesterase were invariably associated with the PSC, suggesting that the PSC developed at the site of the original soleplate. Nerves entered the grafts 10 days postoperatively and contacted the PSC of the regenerating muscle fibers on the 18–20th day. The secondary synaptic clefts of these “reconstructed” soleplates extended far beyond the subaxonal region. A second type of soleplate appeared on the 18–20th day. These soleplates were similar to those found in embryonic muscle and were considered to have been induced to form “de novo” by the presence of the nerves. When grafts were placed in permanently denervated limbs the “reconstructed” soleplates appeared, but the “de novo” type did not. These results shows that information directing the morphogenesis and innervation of the soleplate persists after the original muscle fibers and axons of a graft degenerate and regenerate.en_US
dc.format.extent1640567 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleDevelopment and innervation of soleplates in the freely grafted extensor digitorum longus (EDL) muscle in the raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy, The University of Michigan Medical School, Ann Arbor, MI 48109 ; Department of Anatomy, The University of Detroit School of Dentistry, Detroit, MI 48207en_US
dc.identifier.pmid6638533en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49844/1/1092070107_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ar.1092070107en_US
dc.identifier.sourceThe Anatomical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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