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dc.contributor.authorCoyle, Peteren_US
dc.date.accessioned2007-04-06T18:01:20Z
dc.date.available2007-04-06T18:01:20Z
dc.date.issued1987-05en_US
dc.identifier.citationCoyle, Peter (1987)."Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)." The Anatomical Record 218(1): 40-44. <http://hdl.handle.net/2027.42/49851>en_US
dc.identifier.issn0003-276Xen_US
dc.identifier.issn1097-0185en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49851
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3605659&dopt=citationen_US
dc.description.abstractEarlier studies established that stroke-prone spontaneously hypertensive rats (SHRSP) invariably infarct after middle cerebral artery (MCA) occlusion. Normotensive rats are usually protected from infarction after the occlusion. Objectives of this study were to characterize the anastomosing collaterals that may determine the different outcomes to MCA occlusion in SHRSP and Wistar Kyoto rats (WKY). Young (5–10 week) and old (40–69 week) rats of each sex were anesthetized, then administered papaverine to produce maximal vasodilatation of the cerebrovascular bed. Under control conditions latex was injected into the arterial tree to measure the internal diameter of branches of the anterior cerebral artery (ACA), the MCA, and the ACA-MCA anastomosing collaterals. Large diameter ACA and MCA rami in old, but not young, SHRSP were significantly smaller in diameter than the respective ACA and MCA branches in old WKY. The number of ACA-MCA anastomoses was the same for SHRSP and WKY. Mean internal diameter of the ACA-MCA anastomoses was significantly (p < 0.0001) smaller in SHRSP than WKY in both age groups. There were significant negative correlations between age and (1) the internal diameter of the ACA-MCA anastomoses in WKY but not SHRSP, and (2) the largest diameter ACA and MCA rami in SHRSP but not WKY. The findings suggest that vascular resistance of fully relaxed collaterals is greater in SHRSP than WKY, thereby compromising the dorsal collateral circulation before large diameter vessel changes occur that accompany the established form of hypertension.en_US
dc.format.extent629349 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleDorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, MI 48109en_US
dc.identifier.pmid3605659en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49851/1/1092180108_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ar.1092180108en_US
dc.identifier.sourceThe Anatomical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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