Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)

Show simple item record Coyle, Peter en_US 2007-04-06T18:01:20Z 2007-04-06T18:01:20Z 1987-05 en_US
dc.identifier.citation Coyle, Peter (1987)."Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)." The Anatomical Record 218(1): 40-44. <> en_US
dc.identifier.issn 0003-276X en_US
dc.identifier.issn 1097-0185 en_US
dc.identifier.uri en_US
dc.description.abstract Earlier studies established that stroke-prone spontaneously hypertensive rats (SHRSP) invariably infarct after middle cerebral artery (MCA) occlusion. Normotensive rats are usually protected from infarction after the occlusion. Objectives of this study were to characterize the anastomosing collaterals that may determine the different outcomes to MCA occlusion in SHRSP and Wistar Kyoto rats (WKY). Young (5–10 week) and old (40–69 week) rats of each sex were anesthetized, then administered papaverine to produce maximal vasodilatation of the cerebrovascular bed. Under control conditions latex was injected into the arterial tree to measure the internal diameter of branches of the anterior cerebral artery (ACA), the MCA, and the ACA-MCA anastomosing collaterals. Large diameter ACA and MCA rami in old, but not young, SHRSP were significantly smaller in diameter than the respective ACA and MCA branches in old WKY. The number of ACA-MCA anastomoses was the same for SHRSP and WKY. Mean internal diameter of the ACA-MCA anastomoses was significantly (p < 0.0001) smaller in SHRSP than WKY in both age groups. There were significant negative correlations between age and (1) the internal diameter of the ACA-MCA anastomoses in WKY but not SHRSP, and (2) the largest diameter ACA and MCA rami in SHRSP but not WKY. The findings suggest that vascular resistance of fully relaxed collaterals is greater in SHRSP than WKY, thereby compromising the dorsal collateral circulation before large diameter vessel changes occur that accompany the established form of hypertension. en_US
dc.format.extent 629349 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
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dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cell & Developmental Biology en_US
dc.title Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY) en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, MI 48109 en_US
dc.identifier.pmid 3605659 en_US
dc.description.bitstreamurl en_US
dc.identifier.doi en_US
dc.identifier.source The Anatomical Record en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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