Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)
dc.contributor.author | Coyle, Peter | en_US |
dc.date.accessioned | 2007-04-06T18:01:20Z | |
dc.date.available | 2007-04-06T18:01:20Z | |
dc.date.issued | 1987-05 | en_US |
dc.identifier.citation | Coyle, Peter (1987)."Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY)." The Anatomical Record 218(1): 40-44. <http://hdl.handle.net/2027.42/49851> | en_US |
dc.identifier.issn | 0003-276X | en_US |
dc.identifier.issn | 1097-0185 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49851 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3605659&dopt=citation | en_US |
dc.description.abstract | Earlier studies established that stroke-prone spontaneously hypertensive rats (SHRSP) invariably infarct after middle cerebral artery (MCA) occlusion. Normotensive rats are usually protected from infarction after the occlusion. Objectives of this study were to characterize the anastomosing collaterals that may determine the different outcomes to MCA occlusion in SHRSP and Wistar Kyoto rats (WKY). Young (5–10 week) and old (40–69 week) rats of each sex were anesthetized, then administered papaverine to produce maximal vasodilatation of the cerebrovascular bed. Under control conditions latex was injected into the arterial tree to measure the internal diameter of branches of the anterior cerebral artery (ACA), the MCA, and the ACA-MCA anastomosing collaterals. Large diameter ACA and MCA rami in old, but not young, SHRSP were significantly smaller in diameter than the respective ACA and MCA branches in old WKY. The number of ACA-MCA anastomoses was the same for SHRSP and WKY. Mean internal diameter of the ACA-MCA anastomoses was significantly (p < 0.0001) smaller in SHRSP than WKY in both age groups. There were significant negative correlations between age and (1) the internal diameter of the ACA-MCA anastomoses in WKY but not SHRSP, and (2) the largest diameter ACA and MCA rami in SHRSP but not WKY. The findings suggest that vascular resistance of fully relaxed collaterals is greater in SHRSP than WKY, thereby compromising the dorsal collateral circulation before large diameter vessel changes occur that accompany the established form of hypertension. | en_US |
dc.format.extent | 629349 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Dorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 3605659 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49851/1/1092180108_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ar.1092180108 | en_US |
dc.identifier.source | The Anatomical Record | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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