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Ontogeny of neurotransmitter systems in the paracervical ganglion and uterine cervix of the rat

dc.contributor.authorSullivan, Kelli A.en_US
dc.contributor.authorTraurig, Harold H.en_US
dc.contributor.authorPapka, Raymond E.en_US
dc.date.accessioned2007-04-06T18:01:57Z
dc.date.available2007-04-06T18:01:57Z
dc.date.issued1994-11en_US
dc.identifier.citationSullivan, Kelli A.; Traurig, Harold H.; Papka, Raymond E. (1994)."Ontogeny of neurotransmitter systems in the paracervical ganglion and uterine cervix of the rat." The Anatomical Record 240(3): 377-386. <http://hdl.handle.net/2027.42/49857>en_US
dc.identifier.issn0003-276Xen_US
dc.identifier.issn1097-0185en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49857
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7825734&dopt=citationen_US
dc.description.abstractBackground : The paracervical ganglia (PG) are components of the pelvic plexus that provides sensory and motor innervation to the reproductive system of the female rat. Several neurotransmitters including norepinephrine (NE), acetylcholine (ACh), neuropeptide Y (NPY), and vasoactive intestinal polypeptide (VIP) are present in neurons of the adult PG and in axons innervating the adult uterus and uterine cervix. The current study was undertaken to describe the onset of immunoreactivity of these neurotransmitters and neuropeptides during development. Methods : Female rats, ages E18 to P36, were prepared for immunohistochemistry for TH (tyrosine hydroxylase, a marker of noradrenergic neurons), NPY, or VIP as well as the histochemical demonstration of acetylcholinesterase (AChE). Results : All four markers were detected in neurons of the PG at E18. Changes in the appearance of these markers from E18 to P36 reflected previously described growth changes in the PG. Axons containing AChE, TH, NPY, or VIP were first detected within the cervix at E20. Immunopositive axons first appeared as thick, unbranched structures at the outermost portion of the cervical myometrium. Over time, these axon bundles ramified to form discrete varicose axons. The ingrowth was similar for axons containing each of the four markers. Conclusions : The relative density of each neuronal type in the PG was reflected in the density of axons containing the same marker in the cervix. Changes in neurotransmitter/neuropeptide staining of PG neurons or axons in the cervix were not observed as the animals approached puberty. © 1994 Wiley-Liss, Inc.en_US
dc.format.extent1395152 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleOntogeny of neurotransmitter systems in the paracervical ganglion and uterine cervix of the raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michigan ; Dept. Neurology, University of Michigan, Kresge III, Room 4414, Ann Arbor MI 48109en_US
dc.contributor.affiliationotherDepartment of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentuckyen_US
dc.contributor.affiliationotherDepartment of Anatomical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahomaen_US
dc.identifier.pmid7825734en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49857/1/1092400310_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ar.1092400310en_US
dc.identifier.sourceThe Anatomical Recorden_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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