Show simple item record

Effects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute.

dc.contributor.authorLevy, Michael R.en_US
dc.date.accessioned2007-04-06T18:02:27Z
dc.date.available2007-04-06T18:02:27Z
dc.date.issued1967-04en_US
dc.identifier.citationLevy, Michael R. (1967)."Effects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute. ." Journal of Cellular Physiology 69(2): 247-252. <http://hdl.handle.net/2027.42/49862>en_US
dc.identifier.issn0021-9541en_US
dc.identifier.issn1097-4652en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49862
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6033953&dopt=citationen_US
dc.description.abstractThe effects of actinomycin D, puromycin, and p-fluorophenylalanine on the activation of glyconeogenesis in Tetrahymena were studied. The extent of activation of glyconeogenesis in cultures containing inhibitor was as great as or greater than in the controls, as was the uptake of tracer levels of acetate into glycogen. These increases occurred despite a partial or complete inhibition of synthesis of isocitrate lyase, a glyconeogenic enzyme in Tetrahymena . Washed cells from these cultures could convert tracer or substrate levels of acetate to glycogen at enhanced rates. When glyconeogenesis was activated in starved cells in the presence of inhibitor, there was a negligible increase in the amount of isocitrate lyase, but a significant increase in the rate of glyconeogenesis. The data indicate that glyconeogenesis in Tetrahymena can be activated in the absence of enzyme synthesis.en_US
dc.format.extent532721 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleEffects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michiganen_US
dc.identifier.pmid6033953en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49862/1/1040690215_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jcp.1040690215en_US
dc.identifier.sourceJournal of Cellular Physiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Accessibility: If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.