Effects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute.
dc.contributor.author | Levy, Michael R. | en_US |
dc.date.accessioned | 2007-04-06T18:02:27Z | |
dc.date.available | 2007-04-06T18:02:27Z | |
dc.date.issued | 1967-04 | en_US |
dc.identifier.citation | Levy, Michael R. (1967)."Effects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute. ." Journal of Cellular Physiology 69(2): 247-252. <http://hdl.handle.net/2027.42/49862> | en_US |
dc.identifier.issn | 0021-9541 | en_US |
dc.identifier.issn | 1097-4652 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49862 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6033953&dopt=citation | en_US |
dc.description.abstract | The effects of actinomycin D, puromycin, and p-fluorophenylalanine on the activation of glyconeogenesis in Tetrahymena were studied. The extent of activation of glyconeogenesis in cultures containing inhibitor was as great as or greater than in the controls, as was the uptake of tracer levels of acetate into glycogen. These increases occurred despite a partial or complete inhibition of synthesis of isocitrate lyase, a glyconeogenic enzyme in Tetrahymena . Washed cells from these cultures could convert tracer or substrate levels of acetate to glycogen at enhanced rates. When glyconeogenesis was activated in starved cells in the presence of inhibitor, there was a negligible increase in the amount of isocitrate lyase, but a significant increase in the rate of glyconeogenesis. The data indicate that glyconeogenesis in Tetrahymena can be activated in the absence of enzyme synthesis. | en_US |
dc.format.extent | 532721 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Effects of inhibitors of RNA and protein synthesis on activation of glyconeogenesis in Tetrahymena This investigation was supported by a Public Health Service Postdoctoral Fellowship (2-F2-CA-20,201-02) from the National Cancer Institute. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 6033953 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49862/1/1040690215_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcp.1040690215 | en_US |
dc.identifier.source | Journal of Cellular Physiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.