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The action of mendelian genes in human diploid cell strains The original investigations reported in this paper were supported by NIH Research grant 1-P01-15419-03.

dc.contributor.authorKrooth, Robert S.en_US
dc.contributor.authorSell, Elizabeth K.en_US
dc.date.accessioned2007-04-06T18:02:51Z
dc.date.available2007-04-06T18:02:51Z
dc.date.issued1970-12en_US
dc.identifier.citationKrooth, Robert S.; Sell, Elizabeth K. (1970)."The action of mendelian genes in human diploid cell strains The original investigations reported in this paper were supported by NIH Research grant 1-P01-15419-03. ." Journal of Cellular Physiology 76(3): 311-330. <http://hdl.handle.net/2027.42/49866>en_US
dc.identifier.issn0021-9541en_US
dc.identifier.issn1097-4652en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49866
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4925976&dopt=citationen_US
dc.description.abstractSome of the cells of every human being will grow outside the body as microorganisms. It is possible to show, in a variety of ways, that these cells resemble genetically the individual from whom they were obtained. Over 35 inherited human diseases and anomalies can now be studied in such cell lines. Human diploid cell strains, biochemically marked by one or more mutant Mendelian genes, have proven particularly useful for the study of gene action in man and for the detection of genetic changes such as mutation and somatic cell hybridization. In addition, the strains have a number of clinical applications, including the antenatal diagnosis of inherited disease. The failure of cultured human cells to display their phenotype at most loci continues to restrict their use in both genetics and medicine. There are reasons for hoping that this difficulty will eventually be solved, and some experiments bearing on the problem are already feasible.en_US
dc.format.extent1784367 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleThe action of mendelian genes in human diploid cell strains The original investigations reported in this paper were supported by NIH Research grant 1-P01-15419-03.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLawrence D. Buhl Center for Human Genetics, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104en_US
dc.contributor.affiliationumLawrence D. Buhl Center for Human Genetics, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48104 ; Supported by NIH Training grant 5-T01-GM-00071-13.en_US
dc.identifier.pmid4925976en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49866/1/1040760310_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jcp.1040760310en_US
dc.identifier.sourceJournal of Cellular Physiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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