Viral-induced fusion of human cells. II. Heterokaryocytes between human cells from different donors, and between human cells and those from other species: Formation and properties
dc.contributor.author | Velázquez, Antonio | en_US |
dc.date.accessioned | 2007-04-06T18:03:03Z | |
dc.date.available | 2007-04-06T18:03:03Z | |
dc.date.issued | 1971-08 | en_US |
dc.identifier.citation | VelÁzquez, Antonio (1971)."Viral-induced fusion of human cells. II. Heterokaryocytes between human cells from different donors, and between human cells and those from other species: Formation and properties This work was done in partial fulfillment of the requirements for the Ph.D. degree at the University of Michigan. Supported by Program-Project grant 1-p01-GM-15419-03, from the Public Health Service, U. S. Department of Health, Education and Welfare, to Robert S. Krooth, and by Public Health Research grant CA-04571, from the National Cancer Institute, to Francis E. Payne. ." Journal of Cellular Physiology 78(1): 111-120. <http://hdl.handle.net/2027.42/49868> | en_US |
dc.identifier.issn | 0021-9541 | en_US |
dc.identifier.issn | 1097-4652 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49868 | |
dc.description.abstract | A simple method is described for effecting the formation of heterokaryocytes between different lines of human diploid fibroblasts, and between human diploid fibroblasts and cultured cells derived from other species. In the case of mixed monolayer cultures of human diploid fibroblasts exposed to UV-inactivated Sendai virus, the proportion of nuclei in heterokaryocytes is between 25 and 35%. The heterokaryocytes engage in de novo protein synthesis. No evidence of hybrid enzymes was found in mixed cultures of human and mouse cells which had been exposed to Sendai virus and which therefore presumably contained mouse-human heterokaryocytes. However, with the available data, it is not possible to distinguish between the absence of synthesis of hybrid enzymes and the synthesis of hybrid enzymes in amounts insufficient to permit their detection. | en_US |
dc.format.extent | 922891 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Viral-induced fusion of human cells. II. Heterokaryocytes between human cells from different donors, and between human cells and those from other species: Formation and properties | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan ; Supported by fellowship funds from the Universidad Nacional AutÓnoma de MÉxico. Send reprint requests to: Dr. A. VelÁzquez, Instituto de Investiga-ciones BiomÉdicas, U.N.A.M., Apdo. Postal 70228, MÉxico 20, D.F., MÉxico. | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49868/1/1040780114_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcp.1040780114 | en_US |
dc.identifier.source | Journal of Cellular Physiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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