Postnatal neurogenesis in the kitten retina
dc.contributor.author | Johns, Pamela Raymond | en_US |
dc.contributor.author | Rusoff, Anne C. | en_US |
dc.contributor.author | Dubin, Mark Wm. | en_US |
dc.date.accessioned | 2007-04-06T18:17:31Z | |
dc.date.available | 2007-04-06T18:17:31Z | |
dc.date.issued | 1979-10-01 | en_US |
dc.identifier.citation | Johns, Pamela Raymond; Rusoff, Anne C.; Dubin, Mark Wm. (1979)."Postnatal neurogenesis in the kitten retina." The Journal of Comparative Neurology 187(3): 545-555. <http://hdl.handle.net/2027.42/50008> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50008 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=489792&dopt=citation | en_US |
dc.description.abstract | Postnatal neurogenesis in the kitten retina was studied using 3 H-thymidine radioautography. Kittens were injected with 3 H-thymidine at 1 day, 10 days, 3 weeks or 4 weeks after birth and allowed to survive until 14 weeks of age. Labeled neuronal nuclei were not found in the ganglion cell layer in any of the retinas, but they were seen in the other nuclear layers of the same retinas. In retinas from kittens injected at one day after birth, the peripheral 80% of the length of the retina (in sections cut parallel to the dorsoventral meridian) contained labeled nuclei; the central 20%, around the optic disc, contained no labeled nuclei. Near the ora serrata most nuclei in both inner and outer nuclear layers were labeled. Away from the ora serrata the proportion of labeled to unlabeled nuclei gradually decreased. Labeled nuclei extended farther centrally in the inner than the outer nuclear layer. The same pattern of labeling was repeated in retinas from kittens injected at ten days after birth, but fewer nuclei were labeled, and the central, unlabeled region around the optic disc was longer–55% of the length of the retina. Only a few nuclei near the ora serrata were labeled in retinas from kittens injected at three weeks after birth, and no labeled neurons were found in kittens injected at four weeks. From these results we conclude that all of the ganglion cells in the kitten retina are present by one day after birth, as are all of the other neurons in the central retina. In peripheral regions of the inner and outer nuclear layers, proliferation of cells destined to become neurons continues up to three weeks after birth. | en_US |
dc.format.extent | 979505 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | The Wistar Institute of Anatomy and Biology | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Postnatal neurogenesis in the kitten retina | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy, Medical Science Building II, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Division of Biological Sciences, Natural Sciences Building, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | MCDB, University of Colorado, Box 347, Boulder, Colorado 80309 ; MCDB, University of Colorado, Box 347, Boulder, Colorado 80309 | en_US |
dc.identifier.pmid | 489792 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50008/1/901870306_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cne.901870306 | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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