Show simple item record

dc.contributor.authorKhachaturian, Henryen_US
dc.contributor.authorDores, Robert M.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.contributor.authorAkil, Hudaen_US
dc.date.accessioned2007-04-06T18:19:21Z
dc.date.available2007-04-06T18:19:21Z
dc.date.issued1984-11-10en_US
dc.identifier.citationKhachaturian, Henry; Dores, Robert M.; Watson, Stanley J.; Akil, Huda (1984)."Β-Endorphin/ACTH immunocytochemistry in the CNS of the lizard Anolis carolinensis : Evidence for a major mesencephalic cell group." The Journal of Comparative Neurology 229(4): 576-584. <http://hdl.handle.net/2027.42/50025>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50025
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6094619&dopt=citationen_US
dc.description.abstractThe immunocytochemical distribution of Β-endorphin and other proopiomelanocortin (POMC) peptides in the central nervous system of the lizard Anolis carolinensis was determined. Colchicine pretreatment was used to enhance perikaryal immunoreactivity. A major finding of this study is the localization of a previously undetected mesencephalic cell group which exhibits immunoreactivity to Β-endorphin, ACTH, and Α-MSH. The perikarya of these neurons are large, bipolar, and situated in the mesencephalic tegmental area. They appear to project to the mesencephalic central gray and other brainstem structures. In contrast, the immunoreactive parvicellular perikarya of the medial-basal hypothalamus, corresponding to the POMC perikarya of the rodent arcuate nucleus, exhibit major rostral projections to various telencephalic and diencephalic structures. The exact extent of fiber projections and innervation patterns arising from either of these two groups is not clear at this time and will require further analyses. Scattered fiber immunoreactivity was also seen in the medial cerebral cortex and the striatal complex, regions which apparently are not innervated by Β-endorphin fibers in the rodent brain. Also, no immunoreactivity was seen to an antiserum to the 16K peptide of POMC. Other similarities and differences in the brain distribution of POMC in reptiles and mammals are discussed.en_US
dc.format.extent1283504 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleΒ-Endorphin/ACTH immunocytochemistry in the CNS of the lizard Anolis carolinensis : Evidence for a major mesencephalic cell groupen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid6094619en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50025/1/902290410_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.902290410en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record