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Time of origin of opioid peptide-containing neurons in the rat hypothalamus

dc.contributor.authorKhachaturian, Henryen_US
dc.contributor.authorLewis, Michael E.en_US
dc.contributor.authorAlessi, Norman E.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.date.accessioned2007-04-06T18:19:34Z
dc.date.available2007-04-06T18:19:34Z
dc.date.issued1985-06-22en_US
dc.identifier.citationKhachaturian, Henry; Lewis, Michael E.; Alessi, Norman E.; Watson, Stanley J. (1985)."Time of origin of opioid peptide-containing neurons in the rat hypothalamus." The Journal of Comparative Neurology 236(4): 538-546. <http://hdl.handle.net/2027.42/50027>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50027
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2865278&dopt=citationen_US
dc.description.abstractBy using a combined technique of immunocytochemistry and [ 3 H]thymidine autoradiography, we have determined the “birth date” of opioid pep-tide-containing neurons in several hypothalamic nuclei and regions. These include proopiomelanocortin (POMC) neurons (represented by ACTH immunoreactivity) in the arcuate nucleus; dynorphin A neurons in the supraoptic and paraventricular nuclei and the lateral hypothalamic area; and leuenkephalin neurons in the periventricular, ventromedial, and medial mammillary nuclei, as well as in preoptic and perifornical areas. Arcuate POMC neurons were born very early in embryonic development, with peak heavy [ 3 H]thymidine nuclear labelling occurring on embryonic day E12. Supraoptic and paraventricular dynorphin A neurons were also labelled relatively early (peak at E13). The lateral hypothalamic dynorphin A neurons showed peak heavy labelling also on day E12, By contrast, leu-enkephalin neurons in the periventricular nucleus and medial preoptic area exhibited peak heavy nuclear labelling on day E14. Furthermore, perifornical and ventromedial leu-enkephalin neurons were also born relatively early (peak on days E12 and E13, respectively). However, the leu-enkephalin neurons in the medial mammillary nucleus were born the latest of all cell groups studied (i.e., peak at E15). The results indicate a differential genesis of these opioid peptide-containing neuronal groups in different hypothalamic nuclei and regions.en_US
dc.format.extent965168 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleTime of origin of opioid peptide-containing neurons in the rat hypothalamusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid2865278en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50027/1/902360409_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.902360409en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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