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dc.contributor.authorBernhardt, Robert R.en_US
dc.contributor.authorEaster, Stephen S.en_US
dc.date.accessioned2007-04-06T18:20:00Z
dc.date.available2007-04-06T18:20:00Z
dc.date.issued1986-12-22en_US
dc.identifier.citationBernhardt, R.; Easter, S. S. (1986)."Map of retinal position onto the cross section of the optic pathway of goldfish." The Journal of Comparative Neurology 254(4): 493-510. <http://hdl.handle.net/2027.42/50031>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50031
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3805359&dopt=citationen_US
dc.description.abstractThe position of a retinal cell is defined by the two polar coordinates: r, the distance from the optic disc, and θ the angular (or clock-face) position. Axons of similar θ value were labeled by the punctate application of horseradish peroxidase (HRP) to optic axons in the retina, and axons of similar r-value were labeled by the application of this same marker to a tectal fascicle. Labeled axons were traced in serial transverse sections of the optic pathway from the retina to the tectum to learn the map of the retinal surface onto the cross section of the pathway. Retinas were flat-mounted and treated for HRP to show the retinal origins of the labeled axons. Axons of similar r were clustered together, and the fraction of the pathway's cross-sectional area occupied by the cluster was about the same as the fraction of the retinal area occupied by the group of labeled somata. Axons of similar θ were also clustered, but the fraction of the cross-sectional area they occupied was larger than the fraction of retinal area occupied by their somata. The geometry of the clusters of labeled axons depended on the proximodistal location in the pathway. Near the retina both were stripshaped, but the location and orientation of the strip varied. Both an r-strip and a θ-strip were labeled in some pathways by dual applications of HRP; the two strips were mutually orthogonal at all levels. Each of r and θ mapped onto a separate axis. The axons from most peripheral retina (largest r) were everywhere adjacent to the pia, and axons of progressively more central retina (smaller r) were progressively more separated from the pia (except in the nerve, where the secondary fasciculation complicates the geometry by wrapping old axons in new pia). The map of the circular variable, θ onto a line, required a discontinuity, the location of which differed, depending on the proximodistal level. From the retina to the chiasm, the discontinuity was at the ventral retinal radius (i.e., the right retinal clock-face positions were ordered 6-9-12-3-6 o'clock across the line); just central to the chiasm, the fibers reordered to put the discontinuity at the nasal radius (clock-face positions ordered 3-6-9-12-3); at the brachial bifurcation, the 3-6-9 half turned dorsally, the 9-12-3 half, ventrally. The results are discussed in the context of the growth of the pathway and compared with similar organizational plans in the optic pathways of other vertebrates.en_US
dc.format.extent2268522 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleMap of retinal position onto the cross section of the optic pathway of goldfishen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048en_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048en_US
dc.identifier.pmid3805359en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50031/1/902540404_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.902540404en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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