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Neural induction of taste buds

dc.contributor.authorHosley, Mark A.en_US
dc.contributor.authorHughes, Stephen E.en_US
dc.contributor.authorOakley, Bruceen_US
dc.date.accessioned2007-04-06T18:20:32Z
dc.date.available2007-04-06T18:20:32Z
dc.date.issued1987-06-08en_US
dc.identifier.citationHosley, Mark A.; Hughes, Stephen E.; Oakley, Bruce (1987)."Neural induction of taste buds." The Journal of Comparative Neurology 260(2): 224-232. <http://hdl.handle.net/2027.42/50036>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50036
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3611404&dopt=citationen_US
dc.description.abstractBilateral innervation allows more than 80% of the 610 vallate taste buds to survive removal of one IXth nerve in adult rats. Removal of both IXth nerves in neonatal or adult rats results in the absence of taste buds. In studying development, we found that removing or crushing one IXth nerve in three-day-old neonates profoundly decreased the number of vallate taste buds that subsequently developed. Specifically, after removal of one IXth nerve at 3 days, only 228 taste buds formed, compared with 496 taste buds that one nerve would maintain in adults. Thus, during normal development, the right and left IXth nerves interact synergistically, as at least 150 more taste buds develop than predicted by the sum of the independent action of each IXth nerve. This suggests that vallate taste buds are induced by the IXth nerve. A second example of synergism, representing evidence for the neural induction of taste buds, came from experiments in which we crushed the left IXth nerve 3 days after birth and found that these regenerated IXth nerve axons induced 4 times as many taste buds in the presence of the normal right IXth nerve (118 taste buds) as in its early absence (30 taste buds). We conclude that taste buds are neurally induced and that axons of the IXth nerve interact synergistically in inducing them, rather than competing for targets. We propose that in development innervated progenitor cells form stem cells which lead to taste bud cells.en_US
dc.format.extent1066377 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleNeural induction of taste budsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biology, Neuroscience Laboratory Building, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Biology, Neuroscience Laboratory Building, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumDepartment of Biology, Neuroscience Laboratory Building, University of Michigan, Ann Arbor, Michigan 48109 ; Bruce Oakley, Neuroscience Lab. Bldg., University of Michigan, Ann Arbor, MI 48109en_US
dc.identifier.pmid3611404en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50036/1/902600206_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.902600206en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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