Regenerated optic fibers in goldfish reestablish a crude sectoral order in the visual pathway

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dc.contributor.author Bernhardt, Robert R. en_US
dc.contributor.author Easter, Stephen S. en_US
dc.date.accessioned 2007-04-06T18:21:05Z
dc.date.available 2007-04-06T18:21:05Z
dc.date.issued 1988-11-15 en_US
dc.identifier.citation Bernhardt, Robert; Easter, Stephen S. (1988)."Regenerated optic fibers in goldfish reestablish a crude sectoral order in the visual pathway." The Journal of Comparative Neurology 277(3): 403-419. <http://hdl.handle.net/2027.42/50041> en_US
dc.identifier.issn 0021-9967 en_US
dc.identifier.issn 1096-9861 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50041
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2461975&dopt=citation en_US
dc.description.abstract The goldfish optic pathway is regenerated after an optic nerve crush. We have examined the axonal topography of the regenerated pathway by labeling, with horseradish peroxidase (HRP), axons originating from retinal sectors or annuli. The positions of the labeled axons in the cross section of the pathway were compared to the normal and related to the factors that may influence axonal pathfinding. The positions of retinal axons in the cross section of the normal pathway are predictable from the retinal addresses of the ganglion cells described by the polar coordinates r (the distance from the optic disc) and θ (the sectoral or clockface position). The two coordinates map orthogonally onto the cross section of the pathway; r varies monotonically along one axis; θ varies along a perpendicular axis. The normal r-order, present in the nonregenerated stump of the experimental nerve, was severely degraded and perhaps lost entirely in the regenerated optic nerve, tract, and brachia. Sectoral order was also lost as the axons passed the crush site, but it was reestablished, albeit crudely, in the regenerated tract and brachia where axons tended to occupy positions appropriate to their dorsal, ventral, nasal, and temporal retinal origins. The exit sequence of the regenerated axons from the stratum opticum into the tectal neuropil was normal: temporal first, nasal last. These results suggest that the regenerating fibers followed some θ specific cue located in the nonaxonal environment. It seems likely that the original axons probably followed the same cue. In contrast, the absence of r-order suggests that there is no r-specific cue for the regenerates to follow. It seems likely that the original r-order was a consequence of nonspecific influences—the orderly spatiotemporal growth of the retina and the existence of a permissive region for axonal growth. en_US
dc.format.extent 4854365 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Alan R. Liss, Inc. en_US
dc.publisher Wiley Periodiocals, Inc. en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Regenerated optic fibers in goldfish reestablish a crude sectoral order in the visual pathway en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Biology, The University of Michigan, Ann Arbor, Michigan 48109–1048 en_US
dc.contributor.affiliationum Department of Biology, The University of Michigan, Ann Arbor, Michigan 48109–1048 en_US
dc.identifier.pmid 2461975 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50041/1/902770306_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/cne.902770306 en_US
dc.identifier.source The Journal of Comparative Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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