Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis

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dc.contributor.author Cullinan, William E. en_US
dc.contributor.author Herman, James P. en_US
dc.contributor.author Watson, Stanley J. en_US
dc.date.accessioned 2007-04-06T18:22:48Z
dc.date.available 2007-04-06T18:22:48Z
dc.date.issued 1993-06-08 en_US
dc.identifier.citation Cullinan, William E.; Herman, James P.; Watson, Stanley J. (1993)."Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis." The Journal of Comparative Neurology 332(1): 1-20. <http://hdl.handle.net/2027.42/50057> en_US
dc.identifier.issn 0021-9967 en_US
dc.identifier.issn 1096-9861 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50057
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7685778&dopt=citation en_US
dc.description.abstract The axonal projections of the ventral subiculum to the bed nucleus of the stria terminalis (BST) were examined in the rat with the anterograde neuronal tracer Phaseolus vulgaris - leucoagglutinin (PHA-L). Axons originating in the ventral subiculum coursed to the BST through either the fimbria-fornix, or a pathway involving the stria terminalis via the amygdala. Ventral subicular axons gave rise to dense terminal networks that were preferentially distributed in medial and ventral subregions of the BST. The distribution of subicular fibers and terminals was examined in relation to BST neurons that project to the hypothalamic paraventricular nucleus (PVN). In these cases, discrete iontophoretic injections of the retrograde tracer Fluoro-gold were made in the PVN, with PHA-L delivered to the ipsilateral ventral subiculum. An immunocytochemical double-labeling protocol was then employed for the simultaneous detection of PHA-L and Fluoro-gold, and provided light microscopic evidence for subicular input to PVN-projecting cells located within the BST. In a second series of experiments, the Γ-amino butyric acid (GABA)ergic nature of the BST was examined by in situ hybridization histochemistry for detection of transcripts encoding GAD 67 mRNA. The studies revealed that a high proportion of BST neurons express GAD 67 transcripts. Also, experiments combining Fluoro-gold tracing with GAD 67 in situ hybridization suggested that a proportion of PVN-projecting neurons in the BST are GABAergic. Taken together, the results of these sets of studies suggest that the inhibitory influences of the hippocampus on the PVN might be relayed through specific portions of the BST. These findings may have important implications for our understanding of the neural regulation of the hypothalamic-pituitary-adrenal axis. © 1993 Wiley-Liss, Inc. en_US
dc.format.extent 3408162 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley-Liss, Inc. en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720 en_US
dc.contributor.affiliationum Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720 en_US
dc.contributor.affiliationother Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536-0084 en_US
dc.identifier.pmid 7685778 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50057/1/903320102_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/cne.903320102 en_US
dc.identifier.source The Journal of Comparative Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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