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dc.contributor.authorMarcus, Riva C.en_US
dc.contributor.authorEaster, Stephen S.en_US
dc.date.accessioned2007-04-06T18:23:39Z
dc.date.available2007-04-06T18:23:39Z
dc.date.issued1995-08-28en_US
dc.identifier.citationMarcus, Riva C.; Easter, Stephen S. (1995)."Expression of glial fibrillary acidic protein and its relation to tract formation in embryonic zebrafish ( Danio rerio )." The Journal of Comparative Neurology 359(3): 365-381. <http://hdl.handle.net/2027.42/50065>en_US
dc.identifier.issn0021-9967en_US
dc.identifier.issn1096-9861en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50065
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7499535&dopt=citationen_US
dc.description.abstractTo address possible roles of glial cells during axon outgrowth in the vertebrate central nervous system, we investigated the appearance and distribution of the glial-specific intermediate filament, glial fibrillary acidic protein (GFAP), during early embryogenesis of the zebrafish ( Danio rerio ). Immunopositive cells first appear at 15 hours, which is at the time of, or slightly before, the first axon outgrowth in the brain. Immunopositive processes are not initially present in a pattern that prefigures the location of the first tracts but rather are distributed widely as endfeet adjacent to the pia, overlying most of the surface of the brain with the exception of the dorsal and ventral midline. The first evidence for a specific association of immunopositive cells with the developing tracts is observed at 24 hours in the hindbrain, where immunopositive processes border axons in the medial longitudinal fasciculus. By 48 hours, immunopositive processes have disappeared from most of the subpial lamina and are found exclusively in association with tracts and commissures in three forms: endfeet, radially oriented processes, and tangentially oriented processes parallel to axons. This last form is particularly prominent in the transverse plane of the hindbrain, where they define the boundaries between rhombomeres. These results suggest that glial cells contribute to the development and organization of the central nervous system by supporting early axon outgrowth in the subpial lamina and by forming boundaries around tracts and between neuromeres. The results are discussed in relation to previous results A neuron-glia interactions and possible roles of glial cells in axonal guidance. © 1995 Wiley-Liss, Inc.en_US
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dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley-Liss, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleExpression of glial fibrillary acidic protein and its relation to tract formation in embryonic zebrafish ( Danio rerio )en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-1048 ; Department of pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10082en_US
dc.contributor.affiliationumNeuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-1048 ; Department of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048en_US
dc.identifier.pmid7499535en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50065/1/903590302_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/cne.903590302en_US
dc.identifier.sourceThe Journal of Comparative Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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