Studies on the localization of newly added membrane in growing neurites
dc.contributor.author | Feldman, Eva L. | en_US |
dc.contributor.author | Axelrod, Daniel | en_US |
dc.contributor.author | Schwartz, Michal | en_US |
dc.contributor.author | Heacock, Anne M. | en_US |
dc.contributor.author | Agranoff, Bernard W. | en_US |
dc.date.accessioned | 2007-04-06T18:24:50Z | |
dc.date.available | 2007-04-06T18:24:50Z | |
dc.date.issued | 1981-11 | en_US |
dc.identifier.citation | Feldman, E. L.; Axelrod, D.; Schwartz, M.; Heacock, A. M.; Agranoff, B. W. (1981)."Studies on the localization of newly added membrane in growing neurites." Journal of Neurobiology 12(6): 591-598. <http://hdl.handle.net/2027.42/50076> | en_US |
dc.identifier.issn | 0022-3034 | en_US |
dc.identifier.issn | 1097-4695 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50076 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7310397&dopt=citation | en_US |
dc.description.abstract | Explant culture of the adult goldfish retina results in vigorous neuritic growth, provided that the optic nerve has been previously crushed in vivo. The site of new membrane addition in these growing neurites was studied with a membrane-binding lectin Concanavalin A (Con A) in conjunction with a fluorescent indirect antibody method. Explant cultures were labeled with Con A, followed by rabbit antibodies to Con A. This treatment was shown to immobilize Con A receptors while permitting growth. Twenty-four hours later, the washed preparation was treated with fluorescent goat antirabbit antibodies. The bound fluorescent antibodies appeared as a pattern of contiguous fluorescent speckles confined to the area of old growth while regions near the distal end of the neurite were not fluorescent. These results are compatible with the hypothesis that new membrane is added in the region of the growing tip of the neurite. | en_US |
dc.format.extent | 1230513 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Studies on the localization of newly added membrane in growing neurites | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 7310397 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50076/1/480120607_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/neu.480120607 | en_US |
dc.identifier.source | Journal of Neurobiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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