Changes in intra-axonal calcium distribution following nerve crush
dc.contributor.author | Mata, Marina | en_US |
dc.contributor.author | Staple, Julie | en_US |
dc.contributor.author | Fink, David J. | en_US |
dc.date.accessioned | 2007-04-06T18:24:56Z | |
dc.date.available | 2007-04-06T18:24:56Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Mata, Marina; Staple, Julie; Fink, David J. (1986)."Changes in intra-axonal calcium distribution following nerve crush." Journal of Neurobiology 17(5): 449-467. <http://hdl.handle.net/2027.42/50077> | en_US |
dc.identifier.issn | 0022-3034 | en_US |
dc.identifier.issn | 1097-4695 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50077 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3772363&dopt=citation | en_US |
dc.description.abstract | We used the oxalate-pyroantimonate method to demonstrate the ultrastructural distribution of calcium within rat sciatic nerve 4 h after a crush injury. In normal nerve there are discrete gradients of axoplasmic calcium precipitate with the amount of precipitate decreasing in the axoplasm beneath the Schmidt Lantermann clefts and in the paranodal regions at the node of Ranvier. Near the crush site a marked increase in endoneurial and intra-axonal calcium precipitate correlated with morphologic evidence of axonal degeneration. More distant from the crush site, both in the distal segment destined to degenerate and in the proximal segment destined to regenerate, the most prominent finding was a loss of the normal gradient of precipitate beneath the Schmidt Lantermann clefts. The calcium influx at the crush site corresponds to the known role of calcium in triggering degeneration. The alterations in the distal axon may be an early stage leading to degeneration. Alteration in calcium distribution in the proximal nerve stump may play a role in the regulation of the response to injury. | en_US |
dc.format.extent | 2031334 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Changes in intra-axonal calcium distribution following nerve crush | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 ; Neurology Service (127), 2215 Fuller Road, Ann Arbor, MI 48105 | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 | en_US |
dc.identifier.pmid | 3772363 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50077/1/480170508_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/neu.480170508 | en_US |
dc.identifier.source | Journal of Neurobiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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