Changes in intra-axonal calcium distribution following nerve crush

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dc.contributor.author Mata, Marina en_US
dc.contributor.author Staple, Julie en_US
dc.contributor.author Fink, David J. en_US
dc.date.accessioned 2007-04-06T18:24:56Z
dc.date.available 2007-04-06T18:24:56Z
dc.date.issued 1986-09 en_US
dc.identifier.citation Mata, Marina; Staple, Julie; Fink, David J. (1986)."Changes in intra-axonal calcium distribution following nerve crush." Journal of Neurobiology 17(5): 449-467. <http://hdl.handle.net/2027.42/50077> en_US
dc.identifier.issn 0022-3034 en_US
dc.identifier.issn 1097-4695 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50077
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3772363&dopt=citation en_US
dc.description.abstract We used the oxalate-pyroantimonate method to demonstrate the ultrastructural distribution of calcium within rat sciatic nerve 4 h after a crush injury. In normal nerve there are discrete gradients of axoplasmic calcium precipitate with the amount of precipitate decreasing in the axoplasm beneath the Schmidt Lantermann clefts and in the paranodal regions at the node of Ranvier. Near the crush site a marked increase in endoneurial and intra-axonal calcium precipitate correlated with morphologic evidence of axonal degeneration. More distant from the crush site, both in the distal segment destined to degenerate and in the proximal segment destined to regenerate, the most prominent finding was a loss of the normal gradient of precipitate beneath the Schmidt Lantermann clefts. The calcium influx at the crush site corresponds to the known role of calcium in triggering degeneration. The alterations in the distal axon may be an early stage leading to degeneration. Alteration in calcium distribution in the proximal nerve stump may play a role in the regulation of the response to injury. en_US
dc.format.extent 2031334 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Changes in intra-axonal calcium distribution following nerve crush en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbsecondlevel Psychology en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Social Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 ; Neurology Service (127), 2215 Fuller Road, Ann Arbor, MI 48105 en_US
dc.contributor.affiliationum Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 en_US
dc.contributor.affiliationum Neurology Research Laboratory, University of Michigan and VA Medical Center, Ann Arbor, MI 48105 en_US
dc.identifier.pmid 3772363 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50077/1/480170508_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/neu.480170508 en_US
dc.identifier.source Journal of Neurobiology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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