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Regeneration of goldfish retina: Rod precursors are a likely source of regenerated cells

dc.contributor.authorRaymond, Pamela A.en_US
dc.contributor.authorReifler, Michael J.en_US
dc.contributor.authorRivlin, Patricia K.en_US
dc.date.accessioned2007-04-06T18:25:02Z
dc.date.available2007-04-06T18:25:02Z
dc.date.issued1988-07en_US
dc.identifier.citationRaymond, Pamela A.; Reifler, Michael J.; Rivlin, Patricia K. (1988)."Regeneration of goldfish retina: Rod precursors are a likely source of regenerated cells." Journal of Neurobiology 19(5): 431-463. <http://hdl.handle.net/2027.42/50078>en_US
dc.identifier.issn0022-3034en_US
dc.identifier.issn1097-4695en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50078
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3392530&dopt=citationen_US
dc.description.abstractThis study describes regeneration of the neural retina in juvenile goldfish. The retina was destroyed with an intraocular injection of ouabain, a technique introduced by Wolburg and colleagues (Maier and Wolburg, 1979; Kurz-Isler and Wolburg, 1982). We confirmed their observation that the level of damage produced by the toxin was graded, in that neurons in the inner retinal layers were preferentially destroyed, and only in the more severely affected retinas were cells in the outer nuclear layer (i.e., photoreceptor cells) damaged. Evidence of retinal regeneration could be seen beginning about 2 weeks after the injection of ouabain. In contrast to previous studies (Maier and Wolburg, 1979), we found that regeneration took place only in those retinas in which photoreceptors had been destroyed. In cases in which the outer nuclear layer was spared, no regeneration of inner layers occurred, even after 6 months. Thymidine autoradiography was used to document the regeneration of new retinal neurons and to show that rod precursors, like other dividing cells, were not destroyed by the oubain, but in contrast showed an increased mitotic activity. Regeneration did not proceed uniformly, but was initiated at neurogenic foci scattered across the retina. These foci consisted of clusters of dividing neuroepithelial-like cells. The evidence is consistent with the proposal that these cells were derived from rod precursors. These results imply that rod precursors are capable of a wider range of developmental fates than they normally express.en_US
dc.format.extent2589088 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleRegeneration of goldfish retina: Rod precursors are a likely source of regenerated cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Program, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0616 ; Department of Anatomy and Cell Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0616 ; Department of Anatomy and Cell Biology. P. A. Raymond published previously under the name P. R. Johnsen_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0616en_US
dc.contributor.affiliationumDepartment of Anatomy and Cell Biology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-0616en_US
dc.identifier.pmid3392530en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50078/1/480190504_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/neu.480190504en_US
dc.identifier.sourceJournal of Neurobiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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