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The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse

dc.contributor.authorKanki, John P.en_US
dc.contributor.authorChang, Susannahen_US
dc.contributor.authorKuwada, John Y.en_US
dc.date.accessioned2007-04-06T18:25:47Z
dc.date.available2007-04-06T18:25:47Z
dc.date.issued1994-07en_US
dc.identifier.citationKanki, John P.; Chang, Susannah; Kuwada, John Y. (1994)."The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse." Journal of Neurobiology 25(7): 831-845. <http://hdl.handle.net/2027.42/50085>en_US
dc.identifier.issn0022-3034en_US
dc.identifier.issn1097-4695en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50085
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8089660&dopt=citationen_US
dc.description.abstractA full-length zebrafish cDNA clone and a partial mouse cDNA clone similar to chick DM-GRASP were isolated and analyzed. The nucleotide sequence of the full-length zebrafish clone shares 54% identity, and predicts 39% amino acid identity, with chick DM-GRASP. The partial mouse clone shares 76% nucleotide identity, and predicts 76% amino acid identity, with chick DM-GRASP. The predicted proteins encoded by both of these clones exhibit conserved structural domains that are characteristic of the chick protein. These features may identify them as a distinct subfamily within the immunoglobulin superfamily of cell adhesion molecules. Express of the zebrafish DM-GRASP protein is similar to chick DM-GRASP and is principally restricted to a small subset of developing sensory and motor neurons during axonogenesis. Zebrafish DM-GRASP expression was temporally regulated and limited to specific axon domains. This regional expression correlated with fasciculated axon domains. These results suggest that the zebrafish and mouse cDNA clones represent the respective fish and mammalian homologs of thick DM-GRASP. The highly selective expression of zebrafish DM-GRASP suggests that it is involved in the selective fasciculation and guidance of axons along their normal pathways. 1994 John Wiley & Sons, Inc.en_US
dc.format.extent1570150 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleThe molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048 ; Department of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048en_US
dc.contributor.affiliationumDepartment of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048en_US
dc.contributor.affiliationotherDepartment of Anatomy, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104en_US
dc.identifier.pmid8089660en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50085/1/480250708_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/neu.480250708en_US
dc.identifier.sourceJournal of Neurobiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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