Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome

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dc.contributor.author Donofrio, Peter D. en_US
dc.contributor.author Wilbourn, Asa J. en_US
dc.contributor.author Albers, James W. en_US
dc.contributor.author Do, Lisa Rogers, en_US
dc.contributor.author Salanga, Virgilio en_US
dc.contributor.author Greenberg, Harry S. en_US
dc.date.accessioned 2007-04-06T18:31:07Z
dc.date.available 2007-04-06T18:31:07Z
dc.date.issued 1987-02 en_US
dc.identifier.citation Donofrio, Peter D.; Wilbourn, Asa J.; Albers, James W.; Do, Lisa Rogers,; Salanga, Virgilio; Greenberg, Harry S. (1987)."Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome." Muscle & Nerve 10(2): 114-120. <http://hdl.handle.net/2027.42/50138> en_US
dc.identifier.issn 0148-639X en_US
dc.identifier.issn 1097-4598 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50138
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3029587&dopt=citation en_US
dc.description.abstract Arsenic-induced polyneuropathy is traditionally classified as an axonal-loss type, electrodiagnostically resulting in low amplitude or absent sensory and motor responses, relatively preserved proximal and distal motor conduction rates, and distal denervation. We report four patients with a subacute onset progressive polyradiculoneuropathy following high-dose arsenic poisoning. In three patients, early electrodiagnostic testing demonstrated findings suggestive of an acquired segmental demyelinating polyradiculoneuropathy. Serial testing confirmed evolution into features of a distal dying-back neuropathy. We hypothesize that arsenic toxicity and the resultant biochemical derangement of the peripheral nerve cell leads to subtle changes in axonal function that produce, initially, segmental demyelination and eventually distal axonal degeneration. Acute arsenic toxicity must be suspected in patients with clinical and electrodiagnostic features supporting Guillain-BarrÉ syndrome. en_US
dc.format.extent 666755 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
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dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology and Psychiatry en_US
dc.title Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI ; Department of Neurology, Beowman Gray School of Medicine, 300 South Hawthorne Road, Winston-Salem am, NC 27103 en_US
dc.contributor.affiliationum Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI en_US
dc.contributor.affiliationum Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI en_US
dc.contributor.affiliationother Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH en_US
dc.contributor.affiliationother Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH en_US
dc.contributor.affiliationother Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH en_US
dc.identifier.pmid 3029587 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50138/1/880100203_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/mus.880100203 en_US
dc.identifier.source Muscle & Nerve en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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