Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome
dc.contributor.author | Donofrio, Peter D. | en_US |
dc.contributor.author | Wilbourn, Asa J. | en_US |
dc.contributor.author | Albers, James W. | en_US |
dc.contributor.author | Do, Lisa Rogers, | en_US |
dc.contributor.author | Salanga, Virgilio | en_US |
dc.contributor.author | Greenberg, Harry S. | en_US |
dc.date.accessioned | 2007-04-06T18:31:07Z | |
dc.date.available | 2007-04-06T18:31:07Z | |
dc.date.issued | 1987-02 | en_US |
dc.identifier.citation | Donofrio, Peter D.; Wilbourn, Asa J.; Albers, James W.; Do, Lisa Rogers,; Salanga, Virgilio; Greenberg, Harry S. (1987)."Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome." Muscle & Nerve 10(2): 114-120. <http://hdl.handle.net/2027.42/50138> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50138 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3029587&dopt=citation | en_US |
dc.description.abstract | Arsenic-induced polyneuropathy is traditionally classified as an axonal-loss type, electrodiagnostically resulting in low amplitude or absent sensory and motor responses, relatively preserved proximal and distal motor conduction rates, and distal denervation. We report four patients with a subacute onset progressive polyradiculoneuropathy following high-dose arsenic poisoning. In three patients, early electrodiagnostic testing demonstrated findings suggestive of an acquired segmental demyelinating polyradiculoneuropathy. Serial testing confirmed evolution into features of a distal dying-back neuropathy. We hypothesize that arsenic toxicity and the resultant biochemical derangement of the peripheral nerve cell leads to subtle changes in axonal function that produce, initially, segmental demyelination and eventually distal axonal degeneration. Acute arsenic toxicity must be suspected in patients with clinical and electrodiagnostic features supporting Guillain-BarrÉ syndrome. | en_US |
dc.format.extent | 666755 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Acute arsenic intoxication presenting as guillainbarrÉa-like syndrome | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI ; Department of Neurology, Beowman Gray School of Medicine, 300 South Hawthorne Road, Winston-Salem am, NC 27103 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, and Veterans Administration Hospital, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH | en_US |
dc.contributor.affiliationother | Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH | en_US |
dc.contributor.affiliationother | Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH | en_US |
dc.identifier.pmid | 3029587 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50138/1/880100203_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.880100203 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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