Show simple item record

Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus

dc.contributor.authorBromberg, Mark B.en_US
dc.contributor.authorAlbers, James W.en_US
dc.contributor.authorMcCune, William Josephen_US
dc.identifier.citationBromberg, Mark B.; Albers, James W.; McCune, W. Joseph (1989)."Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus." Muscle & Nerve 12(1): 15-19. <>en_US
dc.description.abstractWe present a patient who developed the Lambert–Eaton myasthenic syndrome (LEMS) in association with systemic lupus erythematosus (SLE). Severe proximal weakness with electrodiagnostic evidence of LEMS developed over 2 days during an exacerbation of cutaneous manifestations (bullous pemphigoid) associated with SLE. Following an increase in the daily dose of prednisone, there was complete clinical restitution of strength within 2 weeks and a slower resolution of electrodiagnostic abnormalities over 6 months. Marked serologic abnormalities were present at the onset and showed improvement over 6–8 months. LEMS had been infrequently described in association with SLE. The immunologic features of both SLE and LEMS suggest a linkage between the two diseases in this patient. We hypothesize that increased antibodies associated with exacerbation of SLE cross reacted with the neuromuscular junction membrane to produce LEMS.en_US
dc.format.extent439212 bytes
dc.format.extent3118 bytes
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleTransient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosusen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan Medical Center, 1920/0316 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109–0316en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.identifier.sourceMuscle & Nerveen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed

Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.


If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.