Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus
dc.contributor.author | Bromberg, Mark B. | en_US |
dc.contributor.author | Albers, James W. | en_US |
dc.contributor.author | McCune, William Joseph | en_US |
dc.date.accessioned | 2007-04-06T18:31:31Z | |
dc.date.available | 2007-04-06T18:31:31Z | |
dc.date.issued | 1989-01 | en_US |
dc.identifier.citation | Bromberg, Mark B.; Albers, James W.; McCune, W. Joseph (1989)."Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus." Muscle & Nerve 12(1): 15-19. <http://hdl.handle.net/2027.42/50142> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50142 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2747733&dopt=citation | en_US |
dc.description.abstract | We present a patient who developed the Lambert–Eaton myasthenic syndrome (LEMS) in association with systemic lupus erythematosus (SLE). Severe proximal weakness with electrodiagnostic evidence of LEMS developed over 2 days during an exacerbation of cutaneous manifestations (bullous pemphigoid) associated with SLE. Following an increase in the daily dose of prednisone, there was complete clinical restitution of strength within 2 weeks and a slower resolution of electrodiagnostic abnormalities over 6 months. Marked serologic abnormalities were present at the onset and showed improvement over 6–8 months. LEMS had been infrequently described in association with SLE. The immunologic features of both SLE and LEMS suggest a linkage between the two diseases in this patient. We hypothesize that increased antibodies associated with exacerbation of SLE cross reacted with the neuromuscular junction membrane to produce LEMS. | en_US |
dc.format.extent | 439212 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan Medical Center, 1920/0316 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109–0316 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2747733 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50142/1/880120104_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.880120104 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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