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Comparison of electrodiagnostic criteria for primary demyelination in chronic polyneuropathy

dc.contributor.authorBromberg, Mark B.en_US
dc.date.accessioned2007-04-06T18:32:26Z
dc.date.available2007-04-06T18:32:26Z
dc.date.issued1991-10en_US
dc.identifier.citationBromberg, Mark B. (1991)."Comparison of electrodiagnostic criteria for primary demyelination in chronic polyneuropathy." Muscle & Nerve 14(10): 968-976. <http://hdl.handle.net/2027.42/50151>en_US
dc.identifier.issn0148-639Xen_US
dc.identifier.issn1097-4598en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50151
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1944409&dopt=citationen_US
dc.description.abstractThree sets of electrodiagnostic criteria for establishing primary demyelination in chronic poly neuropathy are evaluated. Sensitivity is assessed in 70 patients with clinically established chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The criteria use different abnormal values, one adjusts for the effects of axonal loss, while another relies only on conduction velocity. However, even when consideration is given to sufficient number of nerves tested, there is no significant difference ( P = 0.37) in diagnostic sensitivity among them, with 48% to 64% of CIDP patients fulfilling criteria for primary demyelination. Specificity is assessed by applying the criteria to 47 patients with motor neuron disease and 63 patients with diabetic polyneuropathy. No patients meet any of the criteria. Further analysis shows that as sensitivity increases specificity decreases, because of overlapping distributions of nerve conduction abnormalities in these neuropathic disorders. A sensitivity of approximately 66% is a practical limit for electrodiagnostic criteria in CIDP.en_US
dc.format.extent712054 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleComparison of electrodiagnostic criteria for primary demyelination in chronic polyneuropathyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan ; Department of Neurology, University of Michigan Medical Center, Taubman Center 1920/0316, 1500 East Medical Center Drive, Ann Arbor, Ml 48109–0316en_US
dc.identifier.pmid1944409en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50151/1/880141007_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mus.880141007en_US
dc.identifier.sourceMuscle & Nerveen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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