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dc.contributor.authorSimmons, Zacharyen_US
dc.contributor.authorBromberg, Mark B.en_US
dc.contributor.authorFeldman, Eva L.en_US
dc.contributor.authorBlaivas, Milaen_US
dc.date.accessioned2007-04-06T18:32:57Z
dc.date.available2007-04-06T18:32:57Z
dc.date.issued1993-01en_US
dc.identifier.citationSimmons, Zachary; Bromberg, Mark B.; Feldman, Eva L.; Blaivas, Mila (1993)."Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance." Muscle & Nerve 16(1): 77-83. <http://hdl.handle.net/2027.42/50156>en_US
dc.identifier.issn0148-639Xen_US
dc.identifier.issn1097-4598en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50156
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8380902&dopt=citationen_US
dc.description.abstractAlthough polyneuropathies associated with IgM and IgG monoclonal gammopathies have been well described, polyneuropathy with IgA monoclonal gammopathy of undetermined significance (MGUS) is less commonly seen and has not been well studies. We reviewed the clinical and electrodiagnostic features of 5 such patients, and the sural nerve biopsy findings in 4 of them. One patient was diabetic, while 4 were free of other diagnoses commonly associated with neuropathy. Clinical presentations were varied. Electrodiagnostic and histological studies ranged from primary demyelination to primary axon loss to a mixed axonal/demyelinating picture. Three patients who were treated appeared to respond to prednisone or intravenous gamma globulin, despite clear clinical, electrodiagnostic, and histological differences. We conclude that the polyneuropathy associated with IgA MGUS is heterogeneous, similar to that in IgM and IgG MGUS. A trial of immunomodulating therapy appears to be warranted in such patients if the neuropathy is sufficiently servere. © 1993 John Wiley & Sons, Inc.en_US
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dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titlePolyneuropathy associated with IgA monoclonal gammopathy of undetermined significanceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michigan ; Division of Neurology, The Milton S, Hershey Medical Center, PO Box 850, Hershey, PA 17033en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.identifier.pmid8380902en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50156/1/880160113_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mus.880160113en_US
dc.identifier.sourceMuscle & Nerveen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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