Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance
dc.contributor.author | Simmons, Zachary | en_US |
dc.contributor.author | Bromberg, Mark B. | en_US |
dc.contributor.author | Feldman, Eva L. | en_US |
dc.contributor.author | Blaivas, Mila | en_US |
dc.date.accessioned | 2007-04-06T18:32:57Z | |
dc.date.available | 2007-04-06T18:32:57Z | |
dc.date.issued | 1993-01 | en_US |
dc.identifier.citation | Simmons, Zachary; Bromberg, Mark B.; Feldman, Eva L.; Blaivas, Mila (1993)."Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance." Muscle & Nerve 16(1): 77-83. <http://hdl.handle.net/2027.42/50156> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50156 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8380902&dopt=citation | en_US |
dc.description.abstract | Although polyneuropathies associated with IgM and IgG monoclonal gammopathies have been well described, polyneuropathy with IgA monoclonal gammopathy of undetermined significance (MGUS) is less commonly seen and has not been well studies. We reviewed the clinical and electrodiagnostic features of 5 such patients, and the sural nerve biopsy findings in 4 of them. One patient was diabetic, while 4 were free of other diagnoses commonly associated with neuropathy. Clinical presentations were varied. Electrodiagnostic and histological studies ranged from primary demyelination to primary axon loss to a mixed axonal/demyelinating picture. Three patients who were treated appeared to respond to prednisone or intravenous gamma globulin, despite clear clinical, electrodiagnostic, and histological differences. We conclude that the polyneuropathy associated with IgA MGUS is heterogeneous, similar to that in IgM and IgG MGUS. A trial of immunomodulating therapy appears to be warranted in such patients if the neuropathy is sufficiently servere. © 1993 John Wiley & Sons, Inc. | en_US |
dc.format.extent | 572049 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, Michigan ; Division of Neurology, The Milton S, Hershey Medical Center, PO Box 850, Hershey, PA 17033 | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 8380902 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50156/1/880160113_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mus.880160113 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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