How does a key fit a flexible lock? Structure and dynamics in receptor function

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dc.contributor.author Neubig, Richard R. en_US
dc.contributor.author Thomsen, William J. en_US
dc.date.accessioned 2007-04-06T18:36:49Z
dc.date.available 2007-04-06T18:36:49Z
dc.date.issued 1989-11 en_US
dc.identifier.citation Neubig, Richard R.; Thomsen, William J. (1989)."How does a key fit a flexible lock? Structure and dynamics in receptor function." BioEssays 11(5): 136-141. <http://hdl.handle.net/2027.42/50191> en_US
dc.identifier.issn 0265-9247 en_US
dc.identifier.issn 1521-1878 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50191
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2686629&dopt=citation en_US
dc.description.abstract The preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X-ray crystallographic analysis, the methods of molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug design. en_US
dc.format.extent 843434 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cell & Developmental Biology en_US
dc.title How does a key fit a flexible lock? Structure and dynamics in receptor function en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Pharmacology, M6322 Medical Science Bldg. 1, University of Michigan Medical School, Ann Arbor, MI 48109-626, USA en_US
dc.contributor.affiliationum Department of Pharmacology University of Michigan Medical School, Ann Arbor, MI 48109-626, USA en_US
dc.identifier.pmid 2686629 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50191/1/950110506_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/bies.950110506 en_US
dc.identifier.source BioEssays en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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