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dc.contributor.authorNeubig, Richard R.en_US
dc.contributor.authorThomsen, William J.en_US
dc.date.accessioned2007-04-06T18:36:49Z
dc.date.available2007-04-06T18:36:49Z
dc.date.issued1989-11en_US
dc.identifier.citationNeubig, Richard R.; Thomsen, William J. (1989)."How does a key fit a flexible lock? Structure and dynamics in receptor function." BioEssays 11(5): 136-141. <http://hdl.handle.net/2027.42/50191>en_US
dc.identifier.issn0265-9247en_US
dc.identifier.issn1521-1878en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50191
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2686629&dopt=citationen_US
dc.description.abstractThe preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X-ray crystallographic analysis, the methods of molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug design.en_US
dc.format.extent843434 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleHow does a key fit a flexible lock? Structure and dynamics in receptor functionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, M6322 Medical Science Bldg. 1, University of Michigan Medical School, Ann Arbor, MI 48109-626, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology University of Michigan Medical School, Ann Arbor, MI 48109-626, USAen_US
dc.identifier.pmid2686629en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50191/1/950110506_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/bies.950110506en_US
dc.identifier.sourceBioEssaysen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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