How does a key fit a flexible lock? Structure and dynamics in receptor function
dc.contributor.author | Neubig, Richard R. | en_US |
dc.contributor.author | Thomsen, William J. | en_US |
dc.date.accessioned | 2007-04-06T18:36:49Z | |
dc.date.available | 2007-04-06T18:36:49Z | |
dc.date.issued | 1989-11 | en_US |
dc.identifier.citation | Neubig, Richard R.; Thomsen, William J. (1989)."How does a key fit a flexible lock? Structure and dynamics in receptor function." BioEssays 11(5): 136-141. <http://hdl.handle.net/2027.42/50191> | en_US |
dc.identifier.issn | 0265-9247 | en_US |
dc.identifier.issn | 1521-1878 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50191 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2686629&dopt=citation | en_US |
dc.description.abstract | The preceding five years have brought remarkable advances in our understanding of the primary structure of drug receptors. The roles of certain amino acid residues in binding drugs and effecting receptor function have been proposed. As even more detailed structures become available, the goal of rational design of drug molecules based on predicted fits between the drug and its receptor will be near at hand. Although none of the classical receptors has yet yielded to X-ray crystallographic analysis, the methods of molecular biology facilitate the production of the large amounts of these rare proteins necessary for crystallization. Receptor proteins share one fundamental characteristic with allosterically regulated enzymes. Both have the structural flexibility that allows information to be transmitted to distant parts of the molecule. We will discuss recent observations about receptor structure and the dynamic nature of drug receptors, and pose questions about the significance of receptor dynamics for drug design. | en_US |
dc.format.extent | 843434 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | How does a key fit a flexible lock? Structure and dynamics in receptor function | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M6322 Medical Science Bldg. 1, University of Michigan Medical School, Ann Arbor, MI 48109-626, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology University of Michigan Medical School, Ann Arbor, MI 48109-626, USA | en_US |
dc.identifier.pmid | 2686629 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50191/1/950110506_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bies.950110506 | en_US |
dc.identifier.source | BioEssays | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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