Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins
dc.contributor.author | Pratt, William B. | en_US |
dc.date.accessioned | 2007-04-06T18:37:09Z | |
dc.date.available | 2007-04-06T18:37:09Z | |
dc.date.issued | 1992-12 | en_US |
dc.identifier.citation | Pratt, William B. (1992)."Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins." BioEssays 14(12): 841-848. <http://hdl.handle.net/2027.42/50193> | en_US |
dc.identifier.issn | 0265-9247 | en_US |
dc.identifier.issn | 1521-1878 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50193 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1365900&dopt=citation | en_US |
dc.description.abstract | As targeted proteins that move within the cell, the steroid receptors have become very useful probes for understanding the linked phenomena of protein folding and transport. From the study of steroid receptor-associated proteins it has become clear over the past two years that these receptors are bound to a multiprotein complex containing at least two heat shock proteins, hsp90 and hsp56. Attachment of receptors to this complex in a cell-free system appears to require the protein unfolding/folding activity of a third heat shock protein, hsp70. Like the oncogenic tyrosine kinase pp60 src , steroid receptors bind to this complex of chaperone proteins at the time of their translation. Binding of the receptor to the hsp90 component of the system occurs through the hormone binding domain and is under strict hormonal control. The hormone binding domain of the receptor acts as a transferable regulatory unit that confers both tight hormonal control and hsp90 binding onto chimaeric proteins. The model of folding and transport being developed for steroid receptors leads to some general suggestions regarding the folding and transport of targeted proteins in the cell. | en_US |
dc.format.extent | 1050474 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Department of Pharmacology, The University of Michigan Medical School, 6322 Medical Science Building I, Ann Arbor, Michigan 48109-0626, USA | en_US |
dc.identifier.pmid | 1365900 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50193/1/950141209_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bies.950141209 | en_US |
dc.identifier.source | BioEssays | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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