Percutaneous drug penetration: Choosing candidates for transdermal development
dc.contributor.author | Flynn, Gordon L. | en_US |
dc.contributor.author | Stewart, Barbra H. | en_US |
dc.date.accessioned | 2007-04-06T18:39:30Z | |
dc.date.available | 2007-04-06T18:39:30Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Flynn, Gordon L.; Stewart, Barbra (1988)."Percutaneous drug penetration: Choosing candidates for transdermal development." Drug Development Research 13(2-3): 169-185. <http://hdl.handle.net/2027.42/50213> | en_US |
dc.identifier.issn | 0272-4391 | en_US |
dc.identifier.issn | 1098-2299 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50213 | |
dc.description.abstract | There is currently a high level of interest in using the skin as a route for delivering drugs. One hears the questions: What are the attributes of a drug that make it a serious candidate for transdermal delivery? By what a priori analysis might one zero in on the best transdermal candidate within a family of drugs? Answers to these questions lie in understanding the molecular factors that make a drug a facile permeant of the skin. Among other properties, it must have a high absolute affinity for the skin's phases, which provide for its diffusive conduction. Other factors in evaluation are the potency of the drug and the relative efficiency of the drug's systemic presentation once it has gained access to the body. One also considers the potential for the drug to elicit adverse responses in the skin. Fortunately, parallels between the drug's ability to partition between oil and water and its ease of mass transfer across the skin can be used to ferret out a working mass transfer coefficient. If not already known, solubilities are easily experimentally deduced. The extent of first-pass metabolism by the oral route, presumed to be a known quantity, is compared with the relative amount of metabolism of the drug in the course of its diffsion through the skin, an experimentally determined quantity, in order to set the transdermal dose. These bits of information can then be used to form an early, reasonably faithful picture of the feasibility of delivering a particular drug transdermally and to make a first estimate of the size of patch required for the drug. | en_US |
dc.format.extent | 1204818 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry | en_US |
dc.title | Percutaneous drug penetration: Choosing candidates for transdermal development | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, Pharmaceutics Group, College of Pharmacy, The University of Michigan, Ann Arbor ; College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, Pharmaceutics Group, College of Pharmacy, The University of Michigan, Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50213/1/430130209_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ddr.430130209 | en_US |
dc.identifier.source | Drug Development Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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