Show simple item record

dc.contributor.authorBharucha, Vandana A.en_US
dc.contributor.authorPeden, Keith W. C.en_US
dc.contributor.authorSubach, B. R.en_US
dc.contributor.authorNarayanan, V.en_US
dc.contributor.authorTennekoon, Gihan I.en_US
dc.date.accessioned2007-04-06T18:41:09Z
dc.date.available2007-04-06T18:41:09Z
dc.date.issued1993-12-01en_US
dc.identifier.citationBharucha, V. A.; Peden, K. W. C.; Subach, B. R.; Narayanan, V.; Tennekoon, G. I. (1993)."Characterization of the cis -acting elements of the mouse myelin P 2 promoter." Journal of Neuroscience Research 36(5): 508-519. <http://hdl.handle.net/2027.42/50228>en_US
dc.identifier.issn0360-4012en_US
dc.identifier.issn1097-4547en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50228
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7511696&dopt=citationen_US
dc.description.abstractMyelin P 2 is a basic protein of an apparent molecular weight of 14,800. Expression of P 2 has been found largely in the cytosol of Schwann cells in the peripheral nervous system. Although the function of P 2 is unknown, its striking homology to a family of fatty acid binding proteins has led to the idea that P 2 may function as a fatty acid transport molecule. To investigate the DNA elements that control the expression of P 2 , sequences 5′ to the coding region were cloned upstream of the cat reporter gene. A series of 3′ and 5′ promoter mutants was constructed and their activity determined following transfection into secondary Schwann cells and the MT 4 H1 Schwann cell line. Using this strategy, we have identified a 217 bp silencer region and a 142 bp positive regulatory region. In addition, we have localized the 5′ flanking sequences in the promoter that are responsive to cAMP induction and to the transcription factor CCAAT/enhancer binding protein (C/EBP). © 1993 Wiley-Liss, Inc.en_US
dc.format.extent935068 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleCharacterization of the cis -acting elements of the mouse myelin P 2 promoteren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Pediatrics and Neurology, Section of Pediatric Neurology, University of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumDepartments of Pediatrics and Neurology, Section of Pediatric Neurology, University of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumDepartments of Pediatrics and Neurology, Section of Pediatric Neurology, University of Michigan Medical Center, Ann Arbor ; Departments of Pediatrics and Neurology, Section of Pediatric Neurology, R6060 Kresge II, Box 0570, University of Michigan Medical Center, Ann Arbor, MI 48109-0570en_US
dc.contributor.affiliationotherLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Marylanden_US
dc.contributor.affiliationotherDepartment of Pediatrics, University of Pittsburgh, pittsburgh, Pennsylvaniaen_US
dc.identifier.pmid7511696en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50228/1/490360503_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jnr.490360503en_US
dc.identifier.sourceJournal of Neuroscience Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record