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dc.contributor.authorMong, Franz S. F.en_US
dc.date.accessioned2007-04-06T18:45:06Z
dc.date.available2007-04-06T18:45:06Z
dc.date.issued1977-03en_US
dc.identifier.citationMong, Franz S. F. (1977)."Histological and histochemical studies on the nervous influence on minced muscle regeneration of triceps surae of the rat Supported in part by NIH predoctoral training grant and a grant from Muscular Dystrophy Association of America to Dr. B. M. Carlson. , Reported earlier in abstract form (Mong, '75). ." Journal of Morphology 151(3): 451-462. <http://hdl.handle.net/2027.42/50264>en_US
dc.identifier.issn0362-2525en_US
dc.identifier.issn1097-4687en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50264
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=139476&dopt=citationen_US
dc.description.abstractThe degree of minced rat muscle regeneration in the absence of nerve fibers was compared with that of normal regenerates between one and 270 days postoperatively. Up to around 30 days, the number of muscle fibers and their morphology were comparable in both normal innervated and denervated regenerates; both showed clear cross striations and peripherally located nuclei. Histochemically, SDH and myofibrillar ATPase (pH = 9.4) reactions were positive, but there were no typical signs of fiber types in either case of regeneration. The only consistent difference in the early period was the smaller fiber cross sectional areas in denervated regenerates than in innervated ones. Starting about 40 days, the muscle fibers in innervated regenerates became differented into different fiber types (fast-twitch-oxidative-glycolytic, FOG ., fast-twitch-glycolytic, FG., slow-twitch-oxidative, SO .) but there were no such activities in denervated regenerates, although their SDH and myofibrillar ATPase reactions remained positive for a long time. Degenerating muscle fibers could no longer be identified in innervated regenerates. In the denervated regenerates, however, muscle fibers underwent atrophic or degenerative changes and were replaced by connective tissue. The complete disappearance of muscle fibers varied with individual regenerates. In some cases, it occurred about 90 days and in others, traces of muscle fibers could still be seen as late as 150 days postoperatively. Thus, nerves seem to be important primarily in the late phase of regeneration; namely, differentiation of fiber types and maintenance of the structural integrity of muscle fibers.en_US
dc.format.extent2323535 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleHistological and histochemical studies on the nervous influence on minced muscle regeneration of triceps surae of the rat Supported in part by NIH predoctoral training grant and a grant from Muscular Dystrophy Association of America to Dr. B. M. Carlson. , Reported earlier in abstract form (Mong, '75).en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy, University of Michigan, Medical School, Ann Arbor, Michigan 48104 ; This material was taken in part from a thesis for the degree of Doctor of Philosophy, University of Michigan.en_US
dc.identifier.pmid139476en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50264/1/1051510309_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jmor.1051510309en_US
dc.identifier.sourceJournal of Morphologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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