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Inhibition and axial deviation of limb regeneration in the newt by means of a digit implanted into the amputated limb Supported by grants from the Damon Runyan Foundation and the Muscular Dystrophy Association.

dc.contributor.authorCarlson, Bruce M.en_US
dc.date.accessioned2007-04-06T18:45:39Z
dc.date.available2007-04-06T18:45:39Z
dc.date.issued1977-11en_US
dc.identifier.citationCarlson, Bruce M. (1977)."Inhibition and axial deviation of limb regeneration in the newt by means of a digit implanted into the amputated limb Supported by grants from the Damon Runyan Foundation and the Muscular Dystrophy Association. ." Journal of Morphology 154(2): 223-241. <http://hdl.handle.net/2027.42/50268>en_US
dc.identifier.issn0362-2525en_US
dc.identifier.issn1097-4687en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50268
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=926180&dopt=citationen_US
dc.description.abstractThis research was designed to follow up the observation of Thornton and Kraemer ('51) that regressed, denervated limbs of Ambystoma larvae will not regenerate upon reinnervation if all digits on the limbs were not completely resorbed. The object of this experiment was to determine whether the presence of an apical structure, protruding past the amputation surface, would affect the regenerative process. Both forearms of adult newts were amputated midway between the elbow and the wrist. One limb served as a normal regeneration control, and in the other limb the third digit from the removed hand was implanted in place of the removed radius, so that the three distal phalangeal segments protruded past the plane of amputation. Blastema formation in the experimental limbs was delayed by several weeks as compared with control limbs. Approximately one third of the experimental limbs did not regenerate. The regenerates that did form were strongly deviated (45–90°) radially from the longitudinal axis of the limb. Experimental analysis showed that the delay in regeneration is due largely to the projecting part of the digit. The radial deviation of the regenerates is not due to the digital implant, but rather to the removal of the radius. Trauma alone does not account for this phenomenon.en_US
dc.format.extent1487384 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleInhibition and axial deviation of limb regeneration in the newt by means of a digit implanted into the amputated limb Supported by grants from the Damon Runyan Foundation and the Muscular Dystrophy Association.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anatomy, University of Michigan, Ann Arbor, Michigan 48109en_US
dc.identifier.pmid926180en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50268/1/1051540204_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jmor.1051540204en_US
dc.identifier.sourceJournal of Morphologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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