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dc.contributor.authorKowalski, Timothy F.en_US
dc.contributor.authorLee Vahlsing, H.en_US
dc.contributor.authorFeringa, Earl R.en_US
dc.date.accessioned2007-04-06T18:48:48Z
dc.date.available2007-04-06T18:48:48Z
dc.date.issued1979-07en_US
dc.identifier.citationKowalski, Timothy F.; Lee Vahlsing, H.; Feringa, Earl R. (1979)."Lidase treatment of spinal cord transected rats." Annals of Neurology 6(1): 78-79. <http://hdl.handle.net/2027.42/50295>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50295
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=507763&dopt=citationen_US
dc.description.abstractRussian investigators have recently reported clinical recovery of enzyme treated, spinal cord transected rats. Using the exact protocols outlined by Matinian and Andreasian, we repeated a portion of their experiment using a Lidase preparation manufactured in the USSR. Animals were evaluated for return of bladder function, clinical evidence of hind limb motor function, cortical evoked response after sciatic nerve stimulation, and axonal transport of cortically injected tritiated proline by regenerated corticospinal axons. The only difference between treated and control animals was that the mean total body weight of the treated animals increased more than that of controls ( p < 0.05). No animal walked, had return of voluntary motor activity, showed cortical evoked response, or had evidence for transport of tritiated proline over regenerated corticospinal axons.en_US
dc.format.extent233092 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleLidase treatment of spinal cord transected ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Neurology and Pathology, Ann Arbor Veterans Administration and University of Michigan Medical Centers, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology and Pathology, Ann Arbor Veterans Administration and University of Michigan Medical Centers, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology and Pathology, Ann Arbor Veterans Administration and University of Michigan Medical Centers, Ann Arbor, MI ; Chief, Neurology Service (127), Veterans Administration Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105en_US
dc.identifier.pmid507763en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50295/1/410060121_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410060121en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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