Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2007-04-06T18:49:19Z | |
dc.date.available | 2007-04-06T18:49:19Z | |
dc.date.issued | 1983-05 | en_US |
dc.identifier.citation | Johnston, Michael V. (1983)."Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury." Annals of Neurology 13(5): 511-518. <http://hdl.handle.net/2027.42/50300> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50300 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6135388&dopt=citation | en_US |
dc.description.abstract | Vulnerability of neurotransmitter-specific neurons to hypoxia-ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 8% oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic-ischemic injury in full-term human infants. Two weeks after the insult, markers for choinergic, dopaminergic, and Γ-aminobutyric acid–containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other two transmitters. Muscarinic cholinergic receptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult. | en_US |
dc.format.extent | 931316 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Neurotransmitter alterations in a model of perinatal hypoxic-ischemic brain injury | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pediatrics and Neurology, University of Michigan Medical School and Center for Human Growth and Development, 1013 Neuroscience Bldg, 1103 E Huron, Ann Arbor, MI 48109 ; Departments of Pediatrics and Neurology, University of Michigan Medical School and Center for Human Growth and Development, 1013 Neuroscience Bldg, 1103 E Huron, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 6135388 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50300/1/410130507_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410130507 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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