Effects of hypoxia-ischemia on monoamine metabolism in the immature brain
dc.contributor.author | Silverstein, Faye Sarah | en_US |
dc.contributor.author | Johnston, Michael V. | en_US |
dc.date.accessioned | 2007-04-06T18:49:56Z | |
dc.date.available | 2007-04-06T18:49:56Z | |
dc.date.issued | 1984-04 | en_US |
dc.identifier.citation | Silverstein, Faye; Johnston, Michael V. (1984)."Effects of hypoxia-ischemia on monoamine metabolism in the immature brain." Annals of Neurology 15(4): 342-347. <http://hdl.handle.net/2027.42/50306> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50306 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6204578&dopt=citation | en_US |
dc.description.abstract | We measured acute changes in monoamine metabolites in corpus striatum of immature rat pups exposed to hypoxiaischemia, hypoxia alone, or total global ischemia. Carotid ligations and two hours of 8% oxygen environment in 7-day-old pups led to asymmetrical turning behavior, a 70% decrease in endogenous striatal dopamine levels, and a 125% increase in homovanillic acid (HVA) concentrations on the side of ligation. In contrast, hypoxia alone and total global ischemia alone were not associated with HVA level elevation. Elevation of HVA level with hypoxia-ischemia showed a threshold effect between 1 and 1.5 hours, and this time course paralleled that for production of gross morphological changes in rats raised to maturity. The data suggest that dopamine release from striatal nerve terminals is associated with events causing brain injury during perinatal hypoxia-ischemia. Tissue HVA in the animal model appears to be a quantitative marker for the effects of the insult on a population of nerve terminals. | en_US |
dc.format.extent | 761340 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Effects of hypoxia-ischemia on monoamine metabolism in the immature brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Neurology, the University of Michigan Medical Center, Ann Arbor, MI 48109 ; is the recipient of a postdoctoral fellowship from the Medical Research Council of Canada. | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Neurology, the University of Michigan Medical Center, Ann Arbor, MI 48109 ; Department of Center for Human Growth and Development, the University of Michigan, Ann Arbor, MI 48109 ; The University of Michigan, Neuroscience Laboratory Bldg, 1103 E Huron St, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 6204578 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50306/1/410150407_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410150407 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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