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Effects of hypoxia-ischemia on monoamine metabolism in the immature brain

dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorJohnston, Michael V.en_US
dc.date.accessioned2007-04-06T18:49:56Z
dc.date.available2007-04-06T18:49:56Z
dc.date.issued1984-04en_US
dc.identifier.citationSilverstein, Faye; Johnston, Michael V. (1984)."Effects of hypoxia-ischemia on monoamine metabolism in the immature brain." Annals of Neurology 15(4): 342-347. <http://hdl.handle.net/2027.42/50306>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50306
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6204578&dopt=citationen_US
dc.description.abstractWe measured acute changes in monoamine metabolites in corpus striatum of immature rat pups exposed to hypoxiaischemia, hypoxia alone, or total global ischemia. Carotid ligations and two hours of 8% oxygen environment in 7-day-old pups led to asymmetrical turning behavior, a 70% decrease in endogenous striatal dopamine levels, and a 125% increase in homovanillic acid (HVA) concentrations on the side of ligation. In contrast, hypoxia alone and total global ischemia alone were not associated with HVA level elevation. Elevation of HVA level with hypoxia-ischemia showed a threshold effect between 1 and 1.5 hours, and this time course paralleled that for production of gross morphological changes in rats raised to maturity. The data suggest that dopamine release from striatal nerve terminals is associated with events causing brain injury during perinatal hypoxia-ischemia. Tissue HVA in the animal model appears to be a quantitative marker for the effects of the insult on a population of nerve terminals.en_US
dc.format.extent761340 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleEffects of hypoxia-ischemia on monoamine metabolism in the immature brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics and Neurology, the University of Michigan Medical Center, Ann Arbor, MI 48109 ; is the recipient of a postdoctoral fellowship from the Medical Research Council of Canada.en_US
dc.contributor.affiliationumDepartment of Pediatrics and Neurology, the University of Michigan Medical Center, Ann Arbor, MI 48109 ; Department of Center for Human Growth and Development, the University of Michigan, Ann Arbor, MI 48109 ; The University of Michigan, Neuroscience Laboratory Bldg, 1103 E Huron St, Ann Arbor, MI 48109en_US
dc.identifier.pmid6204578en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50306/1/410150407_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410150407en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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