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Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats

dc.contributor.authorBlack, Keith L.en_US
dc.contributor.authorHoff, Julian T.en_US
dc.date.accessioned2007-04-06T18:50:27Z
dc.date.available2007-04-06T18:50:27Z
dc.date.issued1985-09en_US
dc.identifier.citationBlack, Keith L.; Hoff, Julian T. (1985)."Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats." Annals of Neurology 18(3): 349-351. <http://hdl.handle.net/2027.42/50311>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50311
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2996417&dopt=citationen_US
dc.description.abstractTo examine whether leukotrienes could increase blood–brain barrier permeability, rats were anesthetized and injected intravenously with Evans blue. Ten microliters of vehicle, of leukotrienes B 4 , C 4 , or E 4 , or of arachidonic acid was injected over 1 hour directly into the brain parenchyma. The percentage of the total surface area of Evans blue extravasation in a coronal section of brain centered on the injection site was then determined as an estimate of blood–brain barrier permeability. Leukotrienes B 4 , C 4 , and E 4 , and arachidonic acid all increased blood–brain barrier permeability, but this effect was lost when the total dose was reduced to 20 ng. Increased blood–brain barrier permeability induced by arachidonic acid could be prevented by pretreatment with the lipoxygenase inhibitor BW755C, but not with indomethacin. Leukotrienes may play a role in the development of increased blood–brain barrier permeability after cerebral injury.en_US
dc.format.extent312397 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherLittle, Brown and Companyen_US
dc.publisherWiley Periodiocals, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleLeukotrienes increase blood-brain barrier permeability following intraparenchymal injections in ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumSection of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 ; Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumSection of Neurosurgery, University of Michigan, Ann Arbor, MI 48109en_US
dc.identifier.pmid2996417en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50311/1/410180313_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410180313en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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