Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats

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dc.contributor.author Black, Keith L. en_US
dc.contributor.author Hoff, Julian T. en_US
dc.date.accessioned 2007-04-06T18:50:27Z
dc.date.available 2007-04-06T18:50:27Z
dc.date.issued 1985-09 en_US
dc.identifier.citation Black, Keith L.; Hoff, Julian T. (1985)."Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats." Annals of Neurology 18(3): 349-351. <http://hdl.handle.net/2027.42/50311> en_US
dc.identifier.issn 0364-5134 en_US
dc.identifier.issn 1531-8249 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50311
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2996417&dopt=citation en_US
dc.description.abstract To examine whether leukotrienes could increase blood–brain barrier permeability, rats were anesthetized and injected intravenously with Evans blue. Ten microliters of vehicle, of leukotrienes B 4 , C 4 , or E 4 , or of arachidonic acid was injected over 1 hour directly into the brain parenchyma. The percentage of the total surface area of Evans blue extravasation in a coronal section of brain centered on the injection site was then determined as an estimate of blood–brain barrier permeability. Leukotrienes B 4 , C 4 , and E 4 , and arachidonic acid all increased blood–brain barrier permeability, but this effect was lost when the total dose was reduced to 20 ng. Increased blood–brain barrier permeability induced by arachidonic acid could be prevented by pretreatment with the lipoxygenase inhibitor BW755C, but not with indomethacin. Leukotrienes may play a role in the development of increased blood–brain barrier permeability after cerebral injury. en_US
dc.format.extent 312397 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Little, Brown and Company en_US
dc.publisher Wiley Periodiocals, Inc. en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology, and Psychiatry en_US
dc.title Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Psychiatry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 ; Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 en_US
dc.contributor.affiliationum Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 en_US
dc.identifier.pmid 2996417 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50311/1/410180313_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/ana.410180313 en_US
dc.identifier.source Annals of Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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