Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans

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dc.contributor.author Black, Keith L. en_US
dc.contributor.author Hoff, Julian T. en_US
dc.contributor.author McGillicuddy, John E. en_US
dc.contributor.author Gebarski, Stephen S. en_US
dc.date.accessioned 2007-04-06T18:50:52Z
dc.date.available 2007-04-06T18:50:52Z
dc.date.issued 1986-06 en_US
dc.identifier.citation Black, Keith L.; Hoff, Julian T.; McGillicuddy, John E.; Gebarski, Stephen S. (1986)."Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans." Annals of Neurology 19(6): 592-595. <http://hdl.handle.net/2027.42/50315> en_US
dc.identifier.issn 0364-5134 en_US
dc.identifier.issn 1531-8249 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/50315
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3729313&dopt=citation en_US
dc.description.abstract Leukotrines are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene–like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C 4 levels were determined by radioimmunoassay. An index of peritumoral edema was estimated from preoperative contrast-enhanced computed tomographic scans. There was a significant correlation between brain edema and tissue leukotriene levels ( p < 0.003). Metastatic tumors (n = 8) had the highest leukotriene C 4 level at 13.8 ± 8.5 pg/mg tissue (mean ± SE) and the highest index of edema 5.7 ± 1.8. The mean leukotriene C 4 level in the gliomas (n + 5) ws 6.2 ± 2.3 pg/mg tissue and the edema index was 2.1 ± 0.6. There was no edema and no neoplasma in he temporal lobes removed for seizure (n + 2), and their level of leukotriene C 4 was 0.4 ± 0.1 pg/mg tissue. The formation of leukotriene C 4 is stimulated by intracranial tumors. Leukotrienes increase blood–brain barrier permeability and may be important in the formation of vasogenic edema surrounding tumors. en_US
dc.format.extent 462670 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Neuroscience, Neurology, and Psychiatry en_US
dc.title Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Psychiatry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 ; Section of Neurosurgery, 2124 Taubman Health Care Center, Box 0338, University of Michigan Hospitals, Ann Arbor, MI 48109 en_US
dc.contributor.affiliationum Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 en_US
dc.contributor.affiliationum Section of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 en_US
dc.contributor.affiliationum Division of Neuroradiology, University of Michigan, Ann Arbor, MI 48109 en_US
dc.identifier.pmid 3729313 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/50315/1/410190613_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/ana.410190613 en_US
dc.identifier.source Annals of Neurology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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