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Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans

dc.contributor.authorBlack, Keith L.en_US
dc.contributor.authorHoff, Julian T.en_US
dc.contributor.authorMcGillicuddy, John E.en_US
dc.contributor.authorGebarski, Stephen S.en_US
dc.date.accessioned2007-04-06T18:50:52Z
dc.date.available2007-04-06T18:50:52Z
dc.date.issued1986-06en_US
dc.identifier.citationBlack, Keith L.; Hoff, Julian T.; McGillicuddy, John E.; Gebarski, Stephen S. (1986)."Increased leukotriene C 4 and vasogenic edema surrounding brain tumors in humans." Annals of Neurology 19(6): 592-595. <http://hdl.handle.net/2027.42/50315>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50315
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3729313&dopt=citationen_US
dc.description.abstractLeukotrines are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene–like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C 4 levels were determined by radioimmunoassay. An index of peritumoral edema was estimated from preoperative contrast-enhanced computed tomographic scans. There was a significant correlation between brain edema and tissue leukotriene levels ( p < 0.003). Metastatic tumors (n = 8) had the highest leukotriene C 4 level at 13.8 ± 8.5 pg/mg tissue (mean ± SE) and the highest index of edema 5.7 ± 1.8. The mean leukotriene C 4 level in the gliomas (n + 5) ws 6.2 ± 2.3 pg/mg tissue and the edema index was 2.1 ± 0.6. There was no edema and no neoplasma in he temporal lobes removed for seizure (n + 2), and their level of leukotriene C 4 was 0.4 ± 0.1 pg/mg tissue. The formation of leukotriene C 4 is stimulated by intracranial tumors. Leukotrienes increase blood–brain barrier permeability and may be important in the formation of vasogenic edema surrounding tumors.en_US
dc.format.extent462670 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleIncreased leukotriene C 4 and vasogenic edema surrounding brain tumors in humansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumSection of Neurosurgery, University of Michigan, Ann Arbor, MI 48109 ; Section of Neurosurgery, 2124 Taubman Health Care Center, Box 0338, University of Michigan Hospitals, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumSection of Neurosurgery, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumSection of Neurosurgery, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumDivision of Neuroradiology, University of Michigan, Ann Arbor, MI 48109en_US
dc.identifier.pmid3729313en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50315/1/410190613_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410190613en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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