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dc.contributor.authorGilman, Siden_US
dc.contributor.authorDauth, George W.en_US
dc.contributor.authorFrey, Kirk A.en_US
dc.contributor.authorPenney, John B.en_US
dc.date.accessioned2007-04-06T18:51:17Z
dc.date.available2007-04-06T18:51:17Z
dc.date.issued1987-09en_US
dc.identifier.citationGilman, Sid; Dauth, George W.; Frey, Kirk A.; Penney, John B. (1987)."Experimental hemiplegia in the monkey: Basal ganglia glucose activity during recovery." Annals of Neurology 22(3): 370-376. <http://hdl.handle.net/2027.42/50319>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50319
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3674802&dopt=citationen_US
dc.description.abstractUnilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a dense contralateral hemiplegia that recovers partially with time. During the phase of dense hemiplegia, the local cerebral metabolic rate for glucose (lCMRGlc) is decreased significantly in the caudate nucleus, putamen, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus of the hemisphere ipsilateral to the lesion. In the present study, lCMRGlc in the basal ganglia was studied during the phase of partial recovery of motor activity. lCMRGlc was partially restored, and the greatest degree of restoration occurred in structures with direct connections to the cerebral cortex (caudate nucleus, putamen, subthalamic nucleus, substantia nigra, and red nucleus). Restoration was least in structures that do not receive direct connections from the cerebral cortex (the internal and external segments of the globus pallidus). The findings support the hypothesis that corticofugal activity accounts for a substantial degree of functional recovery.en_US
dc.format.extent2578513 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherAmerican Neurological Associationen_US
dc.publisherWiley Periodiocals, Inc.en_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleExperimental hemiplegia in the monkey: Basal ganglia glucose activity during recoveryen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MI 48109 ; Department of Neurology, University of Michigan, 1914/0316. Taubman Health Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0316en_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MI 48109en_US
dc.identifier.pmid3674802en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50319/1/410220314_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410220314en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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