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Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography

dc.contributor.authorFoster, Norman L.en_US
dc.contributor.authorGilman, Siden_US
dc.contributor.authorBerent, Stanleyen_US
dc.contributor.authorMorin, Elizabeth M.en_US
dc.contributor.authorBrown, Morton B.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.date.accessioned2007-04-06T18:52:03Z
dc.date.available2007-04-06T18:52:03Z
dc.date.issued1988-09en_US
dc.identifier.citationFoster, Norman L.; Gilman, Sid; Berent, Stanley; Morin, Elizabeth M.; Brown, Morton B.; Koeppe, Robert A. (1988)."Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography." Annals of Neurology 24(3): 399-406. <http://hdl.handle.net/2027.42/50326>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50326
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3265862&dopt=citationen_US
dc.description.abstractProgressive supranuclear palsy (PSP) is characterized by supranuclear palsy of gaze, axial dystonia, bradykinesia, rigidity, and a progressive dementia. Pathological changes in this disorder are generally restricted to subcortical structures, yet the type and range of cognitive deficits suggest the involvement of many cerebral regions. We examined the extent of functional impairment to cerebral cortical and subcortical structures as measured by the level of glucose metabolic activity at rest. Fourteen patients with PSP were compared to 21 normal volunteers of similar age using 18 F-2-fluoro-2-deoxy-D-glucose and positron emission tomography. Glucose metabolism was reduced in the caudate nucleus, putamen, thalamus, pons, and cerebral cortex, but not in the cerebellum in the patients with PSP as compared to the normal subjects. Analysis of individual brain regions revealed significant Decemberlines in cerebral glucose utilization in most regions throughout the cerebral cortex, particularly those in the superior half of the frontal lobe. Decemberlines in the most affected regions of cerebral cortex were greater than those in any single subcortical structure. Although using conventional neuropathological techniques the cerebral cortex appears to be unaffected in PSP, significant and pervasive functional impairments in both cortical and subcortical structures are present. These observations help to account for the constellation of cognitive symptoms in individual patients with PSP and the difficulty encountered in identifying a characteristic psychometric profile for this group of patients.en_US
dc.format.extent865979 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleCerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomographyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MI ; Department of Neurology, The University of Michigan, 1920 Taubman, Box 0316, 1500 East Medical Center Dr, Ann Arbor, MI 48109-0316en_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MI ; Department of Psychiatry and Psychology, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Biostatistics, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid3265862en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50326/1/410240308_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410240308en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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