Neurological abnormalities associated with remote occupational elemental mercury exposure
dc.contributor.author | Albers, James W. | en_US |
dc.contributor.author | Kallenbach, Lee R. | en_US |
dc.contributor.author | Fine, Lawrence J. | en_US |
dc.contributor.author | Langolf, Gary D. | en_US |
dc.contributor.author | Wolfe, Robert A. | en_US |
dc.contributor.author | Donofrio, Peter D. | en_US |
dc.contributor.author | Alessi, Anthony G. | en_US |
dc.contributor.author | Stolp-Smith, Kathryn A. | en_US |
dc.contributor.author | Bromberg, Mark B. | en_US |
dc.date.accessioned | 2007-04-06T18:52:15Z | |
dc.date.available | 2007-04-06T18:52:15Z | |
dc.date.issued | 1988-11 | en_US |
dc.identifier.citation | Albers, James W.; Kallenbach, Lee R.; Fine, Lawrence J.; Langolf, Gary D.; Wolfe, Robert A.; Donofrio, Peter D.; Alessi, Anthony G.; Stolp-Smith, Kathryn A.; Bromberg, Marchk B. (1988)."Neurological abnormalities associated with remote occupational elemental mercury exposure." Annals of Neurology 24(5): 651-659. <http://hdl.handle.net/2027.42/50328> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50328 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2849369&dopt=citation | en_US |
dc.description.abstract | We examined 502 subjects, 247 of whom had occupational elemental mercury exposures 20 to 35 years previously, to identify potential exposure-related neurological abnormalities. Few significant ( p < 0.05) differences existed between exposed and unexposed subjects. However, multiple linear regression analysis demonstrated several significant correlations between Decemberlining neurological function and increasing exposure as determined by urine mercury measurements from the exposure interval. Subjects with urine mercury peak levels above 0.6 mg/L demonstrated significantly Decemberreased strength, Decemberreased coordination, increased tremor, Decemberreased sensation, and increased prevalence of Babin-ski and snout reflexes when compared with the remaining subjects. Furthermore, subjects with clinical polyneuropathy had significantly higher peak levels than normal subjects (0.85 vs 0.61 mg/L; p = 0.04), but not increased exposure duration (20.1 vs 20.8 quarters; p = 0.34), and 28% of subjects with peak levels above 0.85 mg/L had clinical evidence of polyneuropathy, compared with 10% of remaining subjects ( p = 0.005). Although exposure was not age dependent, several neurological measures showed significant age-mercury interaction, suggesting that natural neuronal attrition may unmask prior exposure-related subclinical abnormalities. | en_US |
dc.format.extent | 972847 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Neurological abnormalities associated with remote occupational elemental mercury exposure | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI ; Departments of Physical Medicine and Rehabilitation, The University of Michigan, Ann Arbor, MI ; University of Michigan Medical Center, 1500 East Medical Center Drive 1C325/OO32 UH, Ann Arbor, MI 48109-0032 | en_US |
dc.contributor.affiliationum | Departments of Environmental and Industrial Health, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Environmental and Industrial Health, The University of Michigan, Ann Arbor, MI ; Department of lnternal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Industrial and Operations Engineering, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Biostatistics, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Physical Medicine and Rehabilitation, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2849369 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50328/1/410240510_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410240510 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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