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dc.contributor.authorAlbers, James W.en_US
dc.contributor.authorKallenbach, Lee R.en_US
dc.contributor.authorFine, Lawrence J.en_US
dc.contributor.authorLangolf, Gary D.en_US
dc.contributor.authorWolfe, Robert A.en_US
dc.contributor.authorDonofrio, Peter D.en_US
dc.contributor.authorAlessi, Anthony G.en_US
dc.contributor.authorStolp-Smith, Kathryn A.en_US
dc.contributor.authorBromberg, Mark B.en_US
dc.date.accessioned2007-04-06T18:52:15Z
dc.date.available2007-04-06T18:52:15Z
dc.date.issued1988-11en_US
dc.identifier.citationAlbers, James W.; Kallenbach, Lee R.; Fine, Lawrence J.; Langolf, Gary D.; Wolfe, Robert A.; Donofrio, Peter D.; Alessi, Anthony G.; Stolp-Smith, Kathryn A.; Bromberg, Marchk B. (1988)."Neurological abnormalities associated with remote occupational elemental mercury exposure." Annals of Neurology 24(5): 651-659. <http://hdl.handle.net/2027.42/50328>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50328
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2849369&dopt=citationen_US
dc.description.abstractWe examined 502 subjects, 247 of whom had occupational elemental mercury exposures 20 to 35 years previously, to identify potential exposure-related neurological abnormalities. Few significant ( p < 0.05) differences existed between exposed and unexposed subjects. However, multiple linear regression analysis demonstrated several significant correlations between Decemberlining neurological function and increasing exposure as determined by urine mercury measurements from the exposure interval. Subjects with urine mercury peak levels above 0.6 mg/L demonstrated significantly Decemberreased strength, Decemberreased coordination, increased tremor, Decemberreased sensation, and increased prevalence of Babin-ski and snout reflexes when compared with the remaining subjects. Furthermore, subjects with clinical polyneuropathy had significantly higher peak levels than normal subjects (0.85 vs 0.61 mg/L; p = 0.04), but not increased exposure duration (20.1 vs 20.8 quarters; p = 0.34), and 28% of subjects with peak levels above 0.85 mg/L had clinical evidence of polyneuropathy, compared with 10% of remaining subjects ( p = 0.005). Although exposure was not age dependent, several neurological measures showed significant age-mercury interaction, suggesting that natural neuronal attrition may unmask prior exposure-related subclinical abnormalities.en_US
dc.format.extent972847 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleNeurological abnormalities associated with remote occupational elemental mercury exposureen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MI ; Departments of Physical Medicine and Rehabilitation, The University of Michigan, Ann Arbor, MI ; University of Michigan Medical Center, 1500 East Medical Center Drive 1C325/OO32 UH, Ann Arbor, MI 48109-0032en_US
dc.contributor.affiliationumDepartments of Environmental and Industrial Health, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Environmental and Industrial Health, The University of Michigan, Ann Arbor, MI ; Department of lnternal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Industrial and Operations Engineering, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Biostatistics, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Physical Medicine and Rehabilitation, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid2849369en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50328/1/410240510_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410240510en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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