Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey
dc.contributor.author | Shimoyama, Ichiro | en_US |
dc.contributor.author | Dauth, George W. | en_US |
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.date.accessioned | 2007-04-06T18:52:22Z | |
dc.date.available | 2007-04-06T18:52:22Z | |
dc.date.issued | 1988-12 | en_US |
dc.identifier.citation | Shimoyama, Ichiro; Dauth, George W.; Gilman, Sid; Frey, Kirk A.; Penney, John B. (1988)."Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey." Annals of Neurology 24(6): 718-726. <http://hdl.handle.net/2027.42/50329> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50329 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3207355&dopt=citation | en_US |
dc.description.abstract | Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a contralateral hemiplegia that resolves partially with time. During the phase of dense hemiplegia, local cerebral metabolic rate for glucose (lCMRGlc) is Decemberreased significantly in most of the thalamic nuclei ipsilateral to the ablation, and there are slight contralateral Decemberreases. The lCMRGlc is reduced bilaterally in most of the brainstem nuclei and bilaterally in the deep cerebellar nuclei, but only in the contralateral cerebellar cortex. During the phase of partial motor recovery, lCMRGlc is incompletely restored in many of the thalamic nuclei ipsilateral to the ablation and completely restored in the contralateral nuclei. In the brainstem and deep cerebellar nuclei, poor to moderate recovery occurs bilaterally. Moderate recovery occurs in the contralateral cerebellar cortex. The findings demonstrate that a unilateral cerebral cortical lesion strongly affects lCMRGlc in the thalamus ipsilaterally and in the cerebellar cortex contralaterally, but in the brainstem bilaterally. Partial recovery of lCMRGlc accompanies the progressive motor recovery. The structures affected include those with direct, and also those with indirect, connections to the areas ablated. | en_US |
dc.format.extent | 960775 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan Medical School, Ann Arbor, MI ; Department of Neurology, 1914/0316 Taubman Center, The University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0316 | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.identifier.pmid | 3207355 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50329/1/410240605_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410240605 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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