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dc.contributor.authorShimoyama, Ichiroen_US
dc.contributor.authorDauth, George W.en_US
dc.contributor.authorGilman, Siden_US
dc.contributor.authorFrey, Kirk A.en_US
dc.contributor.authorPenney, John B.en_US
dc.date.accessioned2007-04-06T18:52:22Z
dc.date.available2007-04-06T18:52:22Z
dc.date.issued1988-12en_US
dc.identifier.citationShimoyama, Ichiro; Dauth, George W.; Gilman, Sid; Frey, Kirk A.; Penney, John B. (1988)."Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey." Annals of Neurology 24(6): 718-726. <http://hdl.handle.net/2027.42/50329>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50329
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3207355&dopt=citationen_US
dc.description.abstractUnilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a contralateral hemiplegia that resolves partially with time. During the phase of dense hemiplegia, local cerebral metabolic rate for glucose (lCMRGlc) is Decemberreased significantly in most of the thalamic nuclei ipsilateral to the ablation, and there are slight contralateral Decemberreases. The lCMRGlc is reduced bilaterally in most of the brainstem nuclei and bilaterally in the deep cerebellar nuclei, but only in the contralateral cerebellar cortex. During the phase of partial motor recovery, lCMRGlc is incompletely restored in many of the thalamic nuclei ipsilateral to the ablation and completely restored in the contralateral nuclei. In the brainstem and deep cerebellar nuclei, poor to moderate recovery occurs bilaterally. Moderate recovery occurs in the contralateral cerebellar cortex. The findings demonstrate that a unilateral cerebral cortical lesion strongly affects lCMRGlc in the thalamus ipsilaterally and in the cerebellar cortex contralaterally, but in the brainstem bilaterally. Partial recovery of lCMRGlc accompanies the progressive motor recovery. The structures affected include those with direct, and also those with indirect, connections to the areas ablated.en_US
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dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleThalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkeyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MI ; Department of Neurology, 1914/0316 Taubman Center, The University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0316en_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, The University of Michigan Medical School, Ann Arbor, MIen_US
dc.identifier.pmid3207355en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50329/1/410240605_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410240605en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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