PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site
dc.contributor.author | Junck, Larry | en_US |
dc.contributor.author | Olson, James M. M. | en_US |
dc.contributor.author | Ciliax, Brian J. | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Watkins, G. Leonard | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | McKeever, Paul E. | en_US |
dc.contributor.author | Wieland, Donald M. | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.contributor.author | Starosta-Rubinstein, Simon | en_US |
dc.contributor.author | Mancini, William R. | en_US |
dc.contributor.author | Kuhl, David E. | en_US |
dc.contributor.author | Greenberg, Harry S. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2007-04-06T18:52:40Z | |
dc.date.available | 2007-04-06T18:52:40Z | |
dc.date.issued | 1989-12 | en_US |
dc.identifier.citation | Junck, Larry; Olson, James M. M.; Ciliax, Brian J.; Koeppe, Robert A.; Watkins, G. Leonard; Jewett, Douglas M.; McKeever, Paul E.; Wieland, Donald M.; Kilbourn, Michael R.; Starosta-Rubinstein, Simon; Mancini, William R.; Kuhl, David E.; Greenberg, Harry S.; Young, Anne B. (1989)."PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site." Annals of Neurology 26(6): 752-758. <http://hdl.handle.net/2027.42/50332> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50332 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2557794&dopt=citation | en_US |
dc.description.abstract | Human gliomas were imaged in vivo using ligands for the peripheral-type benzodiazepine site (or Ω 3 binding site) and positron emission tomography (PET). Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [ 11 C]Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain. In vitro studies of surgically removed specimens of human glioma demonstrated little binding of Ro5-4864 but high levels of binding of another selective ligand, PK 11195. Scans with [ 11 C]PK 11195 demonstrated increased radioactivity in glioma compared to brain in 8 of 10 patients. Radioactivity in tumor and the ratios of radioactivity in tumor to that in remote gray and in white matter correlated significantly with the specific activity of [ 11 C]PK 11195, suggesting that accumulation represents saturable high-affinity binding. We conclude that the PK 11195 manifests greater binding than Ro5-4864 to the peripheral-type benzodiazepine binding site on human gliomas and that human gliomas can be successfully imaged using [ 11 C]PK 11195 and PET. | en_US |
dc.format.extent | 793027 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI ; Department f Neurology 1914/0316 Taubman Center, University of Michigan, Ann Arbor MI 48109 | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Universidad Central de Venezuela, Caracas, Venezuela. University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2557794 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50332/1/410260611_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410260611 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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