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dc.contributor.authorJunck, Larryen_US
dc.contributor.authorOlson, James M. M.en_US
dc.contributor.authorCiliax, Brian J.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorWatkins, G. Leonarden_US
dc.contributor.authorJewett, Douglas M.en_US
dc.contributor.authorMcKeever, Paul E.en_US
dc.contributor.authorWieland, Donald M.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorStarosta-Rubinstein, Simonen_US
dc.contributor.authorMancini, William R.en_US
dc.contributor.authorKuhl, David E.en_US
dc.contributor.authorGreenberg, Harry S.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2007-04-06T18:52:40Z
dc.date.available2007-04-06T18:52:40Z
dc.date.issued1989-12en_US
dc.identifier.citationJunck, Larry; Olson, James M. M.; Ciliax, Brian J.; Koeppe, Robert A.; Watkins, G. Leonard; Jewett, Douglas M.; McKeever, Paul E.; Wieland, Donald M.; Kilbourn, Michael R.; Starosta-Rubinstein, Simon; Mancini, William R.; Kuhl, David E.; Greenberg, Harry S.; Young, Anne B. (1989)."PET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding site." Annals of Neurology 26(6): 752-758. <http://hdl.handle.net/2027.42/50332>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50332
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2557794&dopt=citationen_US
dc.description.abstractHuman gliomas were imaged in vivo using ligands for the peripheral-type benzodiazepine site (or Ω 3 binding site) and positron emission tomography (PET). Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [ 11 C]Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain. In vitro studies of surgically removed specimens of human glioma demonstrated little binding of Ro5-4864 but high levels of binding of another selective ligand, PK 11195. Scans with [ 11 C]PK 11195 demonstrated increased radioactivity in glioma compared to brain in 8 of 10 patients. Radioactivity in tumor and the ratios of radioactivity in tumor to that in remote gray and in white matter correlated significantly with the specific activity of [ 11 C]PK 11195, suggesting that accumulation represents saturable high-affinity binding. We conclude that the PK 11195 manifests greater binding than Ro5-4864 to the peripheral-type benzodiazepine binding site on human gliomas and that human gliomas can be successfully imaged using [ 11 C]PK 11195 and PET.en_US
dc.format.extent793027 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titlePET Imaging of human gliomas with ligands for the peripheral benzodiazepine binding siteen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI ; Department f Neurology 1914/0316 Taubman Center, University of Michigan, Ann Arbor MI 48109en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumUniversidad Central de Venezuela, Caracas, Venezuela. University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine (Department of Internal Medicine), University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid2557794en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50332/1/410260611_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410260611en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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